A Rare but Potentially Treatable Form of Autism

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Researchers at the University of California, San Diego, have identified a rare, hereditary form of autism that may be treatable with nutritional supplements, a new study reports.

The scientists sequenced the genomes of six children with both autism and epilepsy from three Middle Eastern families — in each case, the children’s parents were first cousins — and found that they had mutations in a gene that normally prevents the breakdown of certain amino acids. The end result is that children had low levels of these proteins — known as branched chain amino acids — which the body doesn’t make on its own and must be gotten through food.

Further, the researchers found, mice with the same gene mutation also showed low levels of branched chain amino acids and developed neurological problems, including tremors and epileptic seizures, related to autism. But when the mice were treated with protein supplements that restored depleted levels of the amino acids, their symptoms disappeared within a week.

(MORE: Older Fathers Linked to Children’s Autism and Schizophrenia Risk)

“This might represent the first treatable form of autism,” Joseph Gleeson, lead author and a child neurologist at UCSD, told Nature News. “That is both heartening to families with autism, and also I think revealing of the underlying mechanisms of autism.”

The authors caution, however, that the rare mutation may contribute to only a small number of autism cases. The researchers selected the children in their study to best identify the recessive mutations involved, since there’s an increased likelihood that children from related parents will receive two copies of the mutation.

How that genetic mutation contributes to autism is unclear, but the researchers have a theory. The mutation inactivates a protein called BCKD-kinase, which prevents the breakdown of branched chain amino acids. Normally, these amino acids are ferried across the blood-brain barrier by special transporters. But when their levels drop, the transporters end up carting more of other large amino acids into the brain. These other amino acids serve as precursors for neurotransmitters like dopamine and serotonin, which play a role in mood and pleasure-seeking, and whose activities in the brain may be associated with autism.

When the research team profiled the brains of mice lacking the BCKD-kinase gene, they found very low levels of branched-chain amino acids and very high levels of these other amino acids.

(MORE: Autism: Why Some Children ‘Bloom’ and Overcome Their Disabilities)

“At this point, we do not know if it is the low levels of branched chain amino acids or the high levels of these other neurotransmitter precursors that lead to the autism and epilepsy features. We are trying to differentiate between these now,” said Gleeson in an email.

When the team supplemented the children’s diet with muscle-building supplements rich in branched chain amino acids, it corrected the amino-acid levels in their blood, which the researchers used as a biomarker for successful response. However, they don’t know whether the dietary supplementation will improve the kids’ autism and epilepsy symptoms over time.

“To address this question will require a longer-term study, which is why we labeled this as a ‘potentially-treatable’ form of disease,” says Gleeson. “Importantly, in the animal model we used, we found that the condition was both inducible and reversible, so we have reason to suspect that patients will improve clinically, but it remains to be proven.”

The study was published in the journal Science.

MORE: Why Autistic Kids Make Easy Targets for School Bullies

6 comments
mystyb
mystyb

so where do we buy this?

SAP Training
SAP Training

If you have a relationship with a relative up to the 2nd degree, doesn't that fall under incest?  Anyway, I've got 6 siblings and 4 of us belong to a spectrum of autism. We don't avoid certain foods.  We are who we are, and no food is going to make us 'better'.  I love me the way I am. :) 

EnoughFish
EnoughFish

If they have to differentiate it then why call it Autism?

Scare-mongering sells. Autism, the big, evil target

Tom Watson
Tom Watson

That's why you don't have kids with a close relative.  How long has it been known that inbreeding isn't a good thing?

11genealogist11
11genealogist11

Autism is almost always "treatable" with better nutrition and/or supplements...but the efficacy of treatment varies.  You can always treat a headache with bubblegum.  For some it does nothing, for others it is a miracle. What better nutrition does not and will not do is "cure" autism.

In the rush to find a "cure" for autism, fewer realize it is more an issue of prevention and for that we need to look at a combination of factors that are genetic, epigenetic and nutritional. 

Raggedhand
Raggedhand

Maybe that's why some parents insist that their child's autistic symptoms are treatable with dietary supplements and avoiding certain foods and others say that doesn't work for them.  Maybe both are right.