New Gene Variants Linked to Autism

Researchers come closer to developing a genetic test for the disorder

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In one of the largest-ever studies of genetics and autism, researchers have identified 24 new gene variants associated with autism spectrum disorders (ASD). The work also confirms that 31 variants previously linked to the developmental disorder may serve as useful genetic markers for identifying those with the condition.

Understanding autism’s genetic roots is a priority, researchers say, since it may lead to earlier diagnosis and behavioral intervention, which can improve patient outcomes.

(MORE: Behavior Therapy Normalizes Brains of Autistic Children)

“Oftentimes findings like this get published in academic journals, but they don’t get translated into clinical use,” says Chuck Hensel, an author on the new research study, published in PLoS ONE, who is the senior manager of research at the genetic diagnostics company Lineagen. “Our goal,” Hensel says, “is to try to get these markers into the clinic.”

Hensel teamed with researchers at the University of Utah and the Children’s Hospital of Philadelphia and devised a two-pronged approach for hunting down genetic markers of autism.

First, the researchers chose 55 people living with autism, all from families with many members diagnosed with ASDs. The scientists then sequenced the genomes of these subjects, and compared the genetic profiles to those from a reference population, using the Utah Genetics Reference Project. That allowed them to find regions where the autistic individuals differed from people without the disorder, and led to 153 gene variants, or genetic red flags for the condition.

(MORE: Researchers Discover Genetic Patterns of Autism)

But because ASDs occur in a spectrum of mild to severe symptoms, and the genetic contribution of each of these variants likely varied, they needed to find out which of the 153 aberrations were most strongly linked to autism; some were likely indirectly connected to the disorder, and the scientists wanted to weed out those potential red herrings. So Hensel and his collaborators built a new molecular test, or probe, that would identify the 153 variants from a patient sample of blood, as well as  for 185 other gene variants that previous studies had linked to autism. Running this probe on genetic samples collected from 2,175 children with clinically diagnosed autism spectrum disorders and also from 5,801 children with normal development, they could compare how well each of the variants matched up with an ASD.

Of the 153 initial candidate gene variants, 15 were confirmed as autism-related. The test also picked up another nine autism-related variants that had never  been linked to autism spectrum disorders before. Participants with any of the 24 variants had a two-fold greater risk of developing an ASD than those without the genetic changes.

Of the previously selected 185 genetic variants connected to autism, 31 were also strongly linked with ASDs, but need additional testing to establish how predictive they are of the disorder.

(MORE: Autism Rises: More Children Than Ever Have Autism, But Is the Increase Real?)

Autism researchers suspect that as many as 200 to 400 genes may be responsible for ASDs, and that patients will exhibit a wide array of diverse genetic combinations of these DNA contributors. Not every person with autism will have each and every autism-related gene variant, but it’s likely that he will show some variation of the genetic changes identified in the study. “The bottom line is that autism simply is a lot of different diseases genetically, each of which gives you a similar behavioral result. But they have different causes,” he says.

And that’s why the findings, as encouraging as they are, still can’t be used to diagnose and identify people at risk of developing autism. However, Hensel hopes that large studies like the current one may start to isolate the true genetic predictors of the condition.

“Because of the size of this study, it really gets us to the cusp of using [genetic markers] clinically,” Hensel says. “We wanted to do a big enough study that we could say, yes, these results really mean something.” And hopefully, within a few years, they will.

92 comments
CynthiaParker
CynthiaParker

John,

Your  posts were spot on and very moving. It's tragic that  so many childen's lives must be ruined before this money-driven debacle is halted. Don't pay attention to the pharma sharks who circle in en masse to tear us up, we know what motivates them, don't we? What can we do?

CynthiaParker
CynthiaParker

John Suffolk,

I agree with you. I'm at ciaparker2 which is at gmail.com   Could you contact me? I'd like to help with setting up a way for vaccine autism parents to make common cause.

JohnSuffolk
JohnSuffolk

we need a common face book page for parents with children with Autism after injection to communicate on and perhaps some of these parents may be lawyers or Barristers who will take up a joint cause to pursue these manufacturers of MMR  through courts who have lost cases around world 2012/13 and admitted certain types of children with certain genes are at risk the easy answer is they should look at genes before injecting with a blood tests ..... the U.K is the only one ignoring the truth now and I think Italian ruling set a European president  to open a case in Brussels if not U.K ........the population has a Autistic rate of 6.2%  does not anyone find this alarming !

JohnSuffolk
JohnSuffolk

both of our children two and four years old only  days to weeks after injection stopped  talking and became autistic we will never give them the booster or what its called now the final silence injection .....all round the world 2013  Italy USA France Germany maker of MMR losing cases and paying out only  U.K denying link ......the outcomes are MMR triggers autism .....wake up UK listen to Parents and world wide court rulings Although I believe the Italian one now open gates in U.K for claims ......As for measles we all had it as kids we got it got over it only people with underlying health problems die ..........of coarse the Government want immunisation most of M.Ps have shares in firms !



Read more: http://healthland.time.com/2013/01/15/new-gene-variants-linked-to-autism/#ixzz2VML

goodfather
goodfather

Although i do not believe in giving my child vaccines, its not the cause of his autism. The TV is!..and all other electronics!.. computers, ipads, iphones, video games. My son watched wayyy too much TV at a young age and was diagnosed at around 2 years old. I took it completely away from him, all electronics. He is 3 now, and al i can say is I have my son back. Im telling you people! Technology is backfiring!...We grew up playing board games, playing tag outside, throwing rocks!.. this generation children own ipads at 2. You think i'm crazy?..Look up autistic children on YouTube, 90% of them are stuck in front of a TV or some kind of electronic. 

lilady
lilady

Excellent article and part of the science of genetics that adds to our knowledge about autism.  It's about time that resources are devoted to real science, now that vaccines have been totally exonerated as causing autism.



CynthiaParker
CynthiaParker

There's a genetic tendency to react to vaccines, but if you don't get vaccines, you're fine. My daughter reacted to the hep-B shot at birth, which I had said I didn't want her to get, with four days and nights of endless screaming, vaccine-induced encephalitis. She had started to say two words by 18 months, uh for up and uff for dog, she got the DTaP booster, and bam! completely erased her words, and she didn't say another word until 34 months. She had been diagnosed with autism in the meantime, at 20 months old. All the children who regress after the MMR were fine before they got it, walking, talkiing, socializing, they get the MMR, and bam! they regress into autism and bowel disease. Not born with it. Pushed into it by vaccines. If you avoid vaccines, you too can avoid the encephalitis, heavy metals, and shift from the normal Th-1 immune response to the autoimmune Th-2 response that causes the myriad autoimmune diseases we see everywhere now. Vaccines are the major, if not only, cause of the tsunami of asthma, allergies, bowel disease, celiac disease, gluten intolerance, autism, ADHD, learning disorders, seizure disorders plaguing this generation of children. A purely genetic syndrome wouldn't account for the enormous increase just in the last ten years of all these diseases. And parents are waking up. A Sacramento Bee story last week reported that in some California counties, up to 70% of parents of kindergartners had taken exemptions to the shot requirement.

VacLess
VacLess

Would it be worth adding another couple of variables into the research groups, what other environmental factors could be contributory, childhood immunizations received and when ? Or does this research believe at the outset that environmental factors are not at play ?

Perhaps genes don't articulate the entire picture ? Interesting research but very limited.

I too have read many times there is no such thing as a genetic epidemic.

VictorPavlovic
VictorPavlovic

Its a lie, they don't tell you in the U.S. Media that vaccines actually cause autism, all they do is bring in an so called expert doctor that regurgitates old, tired useless information, and tells you that there is no connection.What kind of person could be considered an expert when the average parent of a vaccine injured child knows more about autism.The autism research funded by the government has been on dead end roads ever since it decided to go down that one way street of genetic research, since we all know, there is no such thing as an genetic epidemic!

JennyAllan
JennyAllan

Quote from above :-

"Hensel says. “We wanted to do a big enough study that we could say, yes, these results really mean something.” And hopefully, within a few years, they will."

So, can we all assume these research so called 'results' don't actually mean a damn thing!!  We can't wait 'a few years' to address the obviously environmental causes of autism.

AndrewKilroy
AndrewKilroy

It seems that there is a convinced lobby of scumbags insisting that I am the product of an MMR jab. They're the lesser evil. The worst are those ready to use this scientific information to scrub us from existence.

alpha
alpha

I believe that the mercury in the MMR shots may have had something to do with it I also remember hearing mercury has some neurological effects

I happen to have autism and people need to know more about it instead of just assuming it is a disease that negatively effects a person.

Autism actually has major advantages such as being better at math and algebra than others. I seem to think outside the box and come up with ideas faster than any of my classmates.

JohnStone
JohnStone

What a load of bluff. The genetic model for autism failed long ago - all they have got is an ever more tenuous collection of statistical associations, and they are very excited because the more tenuous and diffuse it gets the more money they can demand to plug the ever increasing gaps. And note we are not talking about genetic determination, we are talking about genetic susceptibility. Gullible journalists think they are getting a story about genes, but actually it is about toxic environmental insult which is what, urgently, we should be researching, instead of wasting money on this junk. Twenty years from now these guys will still be saying "we don't know what causes autism" and slapping each other on the back.

AlbusNerdisky
AlbusNerdisky

I take comfort from the fact that anyone that makes a bit of effort can easily see how the anti-vaccs have fabricated the “enormous increase” in autism….how these children were not “fine” prior to the regression…and how the anti-vaccs have actively tried to deceive parents and hide the data that shows the autism predates the vaccination.

They can also follow how the same few people still keep making the same false claims year after year after year…..

W&N

CrystalJadeSadger
CrystalJadeSadger

@VacLess  yes they do say that it isn't just genetics, yet they rule out vaccines even though most parents do not notice an extreme change til after so many immunizations. My daughter was  typical child, only thing behind in was speech. I have known many people whose speech was behind and are now highly intelligent people. I thnk that yes genetics are at play and that certain people with these genes have a sort of allergic reactions to the amt of vaccines given to them in the first couple of yrs. I know I read about some other countries who wait to give immunizations after age 3 since the first 3 yrs are very important yrs of brain development and they have no where near the amt of autism cases as the united states. they mention adhd, my oldest was delayed and behind with speech and is sdhd. my middle daughter autistic. My youngest has not had immunization since age of 12 to 15 months. she is ahead a bit for her age. she is 2 1/2. shortly after age one she started learning shapes, colors, numbers etc. She recognizes many shapes including octagon. many people are surprised at well she talks. she sings her abcs and recognizes almost all her letters. she attempts to count to 20 but counts to ten well and recognizes numbers up to 10. I will not immunize her again til after age 3 and one at a time spread out while I keep a close eye on her. any changes I will stop immunizations altogether. I believe my autistic daughter has had no shots since age 4. I am scared she will regress more if I do

CynthiaParker
CynthiaParker

I think genes definitely set a threshold which must be reached before vaccine damage occurs, but people have very different thresholds. But everyone will be pushed into damage once his level is reached, and so we see skyrocketing figures for many vaccine-induced conditions as more and more people are toppled over their personal limit.

AlbusNerdisky
AlbusNerdisky

You didn’t actually read the paper before commenting did you?

Oh, and can you give us one example of an epidemiologist that believes there is an epidemic of autism?

W&N

AlbusNerdisky
AlbusNerdisky

Well….we don’t need to assume, we can clearly see from your posting that you didn’t understand the comment.

You should try reading the entire sentence again.

W&N

lilady
lilady

@AnneDachel1Your first reference to the Italian Magistrates decision to award damages to a child whose parent claimed their child's autism was caused by the MMR vaccine, is presently in the appeal stages, Ms. Dachel.  That original decision was based on "expert witnesses" testimony using the fraudulent research of Andrew Wakefield.  Here for the umpteenth time, plus...is the PubMed listing of 328 studies that disprove any link between between MMR vaccine and the onset of autism:


http://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=19952979


Your other link to a blog by David Kirby who *claims* that the California child was compensated for "autism" is utterly false as well.  I've read all the legal papers that are available on the internet and the child was awarded damages by the Vaccine Court for a "Table Injury" (evidence of encephalitis/encephalopathy) within 15 days of the child receiving a vaccine.  

Please read the Vaccine Court's decision, Ms. Dachel.  Please shows us where the Vaccine Court awarded damages for "Autism" and finally, stop putting your own spin on the Vaccine Court's decision.  Thank you.


CynthiaParker
CynthiaParker

There's no mercury in the MMR since it's a live vaccine. The measles vaccine virus can go through the gut and show up in the brain and the spinal fluid of those who develop autism shortly after getting the MMR. It may be that the live measles virus interacts with mercury stored from previous vaccines, causing severe symptoms of mercury toxicity (autism and bowel disease).

lilady
lilady

@alpha You may have an advantage when it comes to math and algebra, but that "advantage" does not mean that you understand the difference between organomercury compounds (ethylmercury) such as the preservative Thimerosal and elemental Hg/inorganic mercury (methylmercury).  


You would do well to brush up on your knowledge of organic and inorganic mercury, their profound differences within humans, their rate of excretion through the gut (ethylmercury/organomercury/Thimerosal-vs-the inability of the body to excrete elemental Hg/methyl mercury/inorganic mercury which accumulates in major organs.  (hint) Elemental Hg and methyl mercury are products of heavy industrial manufacturing.  It pollutes our waterways and foodfish/shellfish. It accumulates within the human body and causes heavy metal toxic levels within humans.

AlbusNerdisky
AlbusNerdisky

I think you are referring to chimerical--which was never in MMR vaccines.

W&N

lilady
lilady

@JohnStone What a load of bluff you and your anti-vaccine organization Age of Autism are.  Each and every time a gene variation is identified or  de novo genes are identified, you and your pals at AoA become less relevant.  The only toxic environment we can prove is the environment that surrounds AoA and your goal to spread fear, uncertainty and doubt.  


When your *journalists* attempt to do research they are abject failures.  Why not leave the research up to real researchers and real scientists, Stone?  Why don't you and your pals admit that you refuse to read the science and the many studies that prove there is no connection between any vaccine, any ingredient in vaccines, the timing of vaccines and the onset of autism.  


Stop try to play geneticists and accept your autistic children.  Stop trying to *treat/recover/cure* autistic kids with dangerous, painful treatments such as bleach enemas, chelation for non-existent heavy metal toxicities and chemical castrations.

AlbusNerdisky
AlbusNerdisky

John Stone--UK editor of Age of Autism,

What a shame that in its 5+ years of existence Age of Autism, the staff haven’t cared enough about getting the science correct to have actual scientists on staff.

(A) Of course a geneticist would explain how Age of Autism is entirely wrong in their comments about the genetics of autism.

BTW #1: when you describe statistical analysis as being “tenuous” when the p values are in the range of 10e(-20) to 10e(-55) you demonstrate that you have zero comprehension of the data.

BTW #2: when you describe the study as being “ statistical associations” you demonstrate the you have utterly failed to understand the study. One of its major points being the identification of genetic networks important in neuronal development.

(B) And a neurobiologist would explain the data showing that the etiology of autism occurs in utero.

(C) And many different scientists could explain how the data from A and B are being used to develop potential treatments/cures for autism.

Too bad such important information is ruthlessly censored at Age of Autism.

But then how would Age of Autism make money helping to sell “snake oil” if they told the truth?

W&N

CynthiaParker
CynthiaParker

In 1988, when Rain Man came out, doctors were told that they'd probably go through all their professional life and never see a person with autism. In the 1980s, incidence in the U.S. was only three in every ten thousand. Then numbers started to climb precipitously with the start of the criminal hep-B at birth vaccine campaign that started in 1991. Even ten years ago, it was "only" one in 150. Now it's one in fifty (the one in 88 was for those born, like my daughter, in 2000. It's  not due to better diagnosis, it's not that they've always been around in the same numbers. If that were true, schools could trundle on like they always have, but instead, schools are falling apart under the huge numbers of severely impaired children pouring in. Most of these children will never be independent, and will depend on the government to support them. People can wake up now and put a halt to the vaccine epidemic, or they can see their taxes double and triple in the near future to care for the autistic.

AlbusNerdisky
AlbusNerdisky

I think that there is a zero % chance that you will ever try and use actual science/scientists to support your POV.

Can’t have folks with knowledge, understanding, information and ability correcting all your errors now can we….

W&N

lilady
lilady

@AlbusNerdisky Apparently most of the commenters here did not read the paper W&N.  They are the denizens that haunt anti-vaccine blogs that provide their sole "scientific" sources.


It's about time that resources and research is devoted to the study of de novo gene mutations and away from the pseudoscience of the failed vaccine-autism link.

AlbusNerdisky
AlbusNerdisky

Of course there is mercury in MMR…there is mercury in everything on earth…there is no thimerosal in MMR.

It is interesting that no matter how many years this goes on the anti-vaccs simply refuse to get their virology from virologists. Bizarrely the anti-vaccs get angry when the world rejects their wacky fabrications about virus and the etiology of autism.

W&N

lilady
lilady

@AlbusNerdisky My, my Mr. Stone is having a meltdown here.  He's indignant that his pseudoscience that he posts on AoA, is not being accepted in any science circle.  He's throwing out fresh meat to his groupies at AoA and absolutely frothing at the mouth, that you  are providing some real science about autism and supportive of the ongoing research into the causes of ASDs.

JohnStone
JohnStone

I was commenting on the genre, not this study which I haven't seen and doesn't yet appear to be on-line . So, you have an advantage over me, which is interesting since you don't say who you are.

As long ago as 2006 Francis Collins - then head of the genome project and now head of NIH - warned Congress that the autism explosion couldn't be genetic.


“Genes alone do not tell the whole story. Recent increases in chronic diseases like diabetes, childhood asthma, obesity or autism cannot be due to major shifts in the human gene pool as those changes take much more time to occur. They must be due to changes in the environment, including diet and physical activity, which may produce disease in genetically predisposed persons."

That doesn't sound particularly in utero to me. Meanwhile the US government continues to dismiss with brutal contempt parents who report the adverse effects of their vaccine programme and the mainstream media fails to report the major concessions in the vaccine court.

http://www.huffingtonpost.com/david-kirby/post2468343_b_2468343.html

 Hit and run perhaps. Today there is an article in New Scientist saying that mercury in thimerosal isn't toxic. You guys appear to be getting desperate.

AlbusNerdisky
AlbusNerdisky

Wow-today we know of data that Kanner wasn’t aware of. Shocking isn’t it?

What is revealing is that you didn’t care enough to even ask for the data. Shows where your true priorities are.

W&N

CynthiaParker
CynthiaParker

Well, this is what the neurologist Leo Kanner said in his landmark article "Autistic Disturbance of Affective Contact," , in which he coined the word autism, published in the Nervous  Child in 1943:

"Since 1938, there have come to our attention a number of children whose condition differs so markedly and uniquely from anything reported so far, that each case merits - and, I hope, will eventually receive - a detailed consideration of its fascinating peculiarities"

H

AlbusNerdisky
AlbusNerdisky

2 of 2

BTW: Autism was clearly identified long before Kanner--naturally the anti-vaccs censor this information.

BTW: I did read Age of Autism. I just don’t know how anyone could make it through middle-school and honestly believe it. Can you honestly say that you have ever asked an epidemiologists to explain the epidemiology of autism? Nope….didn’t think so.

W&N

AlbusNerdisky
AlbusNerdisky

1 of 2

It is interesting that no matter how many years this goes on the anti-vaccs simply refuse to even look at the neurobiology/genetic research on autism. The comments on this board are a good example of this willful ignorance.

For those that care enough about the truth to ask actually qualified scientists, they will learn how molecular lesions causatively involved in the development of autism are being defined and how they occur in early embryonic development. Naturally the anti-vaccs ruthless censor this information which has been accumulating for 40+ years.

AlbusNerdisky
AlbusNerdisky

It is interesting that no matter how many years this goes on, the anti-vaccs simply refuse to get their epidemiology of autism from actual epidemiologists.

For those interested in the truth the facts are obvious: the rate of autism has always been ~1% and the vast majority of people with autism will in fact be independent to the extent that they live in the community.

Most people have woken up to the fact that the anti-vaccs are not truthful.

W&N

CynthiaParker
CynthiaParker

It's also interesting after reading this article about a study looking for genes associated with autism to remember that twelve year study of 19,000 women to study 101 genes linked to heart disease. The study found that the genes had no predictive value as to ultimate outcome. These studies on autism genes will not yield any valuable information either. The relevant genes predispose to vaccine reaction, and do not in themselves cause autism. How could they? Autism only started in the 1930s, with the advent of the first mercury-containing diphtheria vaccines and fungicides. Dr. Kanner wrote in 1943 that the condition was so unusual that, had it existed before, someone would have noticed it and described it, but no one had. Read the book The Age of Autism.

lilady
lilady

@AlbusNerdisky And, the denizens of AoA just keep cranking out their spamming comments and claims that their children are *damaged* by vaccines.  What an awful way to refer to their children.

 They also keep subjecting their children to bleach enemas, chelation and chemical castration.  They keep taking their autistic children to unlicensed offshore clinics for painful intrathecal IV infusions after their DAN! practitioners, using bogus blood tests, tell them their children are "toxic".

JohnSuffolk
JohnSuffolk

@lilady @AlbusNerdisky both my children fine till this injection read the court ruling all round the world it does not cause Autism it triggers  it the makers are now admitting this !

AlbusNerdisky
AlbusNerdisky

If you understood the sentence, then why did you post something that isn’t true?

I think you still haven’t understood Hensel’s comment.

W&N

lilady
lilady

@JohnStone Maybe you would care to explain why I post under a pseudonym Mr. Stone.

Tell us about you and your pals who have deluged the workplaces of at least two science bloggers (a respected breast cancer surgeon/breast cancer researcher and an epidemiologist)...in efforts to have them lose their jobs.

Tell us about the AoA "journalist" who stalks respected scientists, physicians and journalists at public meetings and then posts about his activities.

I've read some of your columns Mr. Stone and your posts on other blogs... and you are clueless about basic science, no less organic and inorganic chemistry, immunology, virology, bacteriology and epidemiology.




lilady
lilady

@AlbusNerdisky @lilady Have you seen the list of "speakers" at AoA's affiliated group's (Generation Rescue/Autism One) 2013 Convention...Andrew Wakefield, Mark and David Geier and the purveyor of MMS bleach?

You remember what MMS bleach is, don't you?  It is an industrial bleach product used for oral dosing and for enemas, based on the premise that credulous parents of autistic children think of them as infected with (imaginary) parasites which *might be* a cause of their autistic behaviors.  (No matter that ova and parasite stool studies conducted by reliable laboratories do not find any evidence of parasitic infestations).  

Some set of rogue practitioners that AoA and its affiliates promote as heroes and heroines.


AlbusNerdisky
AlbusNerdisky

Mr Stone,... on Wakefield,

Here is what the Court actually said:

“There is now no respectable body of opinion which supports his hypothesis, that MMR vaccine and autism/enterocolitis are causally linked.”

http://www.bailii.org/ew/cases/EWHC/Admin/2012/503.html

You have grossly miss-represented the most basic facts of Mr. Justice Mitting’s rulings and his reason‘s for overturning the GMC ruling.

It is pointless to go line by line through the mountain of misinformation at Age of Autism on Wakefield, bottom line is that the facts, words, ethics, science, etc are all systematically miss-represented..

In summary, it is impossible to have the most basic literacy skills and the integrity to fact-check and to not be appalled by the staggering abuse of the autism community by Age of Autism and their continued suppression of the truth about the science of autism and misconduct of the anti-vaccs.

W&N

lilady
lilady

@AlbusNerdisky Hah, so it was the castrating/chelating Geiers who made that specious allegation against Pichichero, eh?

That would be Dr. Mark Geier who has since had his medical license revoked or suspended in 9 of the 10 states where he set up castrating/chelating clinics.  (I expect that Hawaii will shortly take action against Dr. Geier.)  After he lost his license, he continued to use his prescription pad to get certain drugs for himself and members of his family.


His son David Geier was charged by the State of Maryland with "practicing medicine without a license" and fined $10,000 for that offense.  I expert that there will be criminal charges that they both will be facing for their abuse of developmentally disabled children and for defrauding insurance companies, as well.

 Some set of rogue ex-medical doctors that AoA honors as heroes.




AlbusNerdisky
AlbusNerdisky

Ethics 2 of 2

3. The fabricated “problem” come from notorious anti-vaccs who personally profited from this fabrication.

It was exactly addressed in the Lancet more than 8 years ago.http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)17134-1/fulltext

Conclusion: the anti-vaccs are trying to deceive parents into discounting important safety data through fabricated character attacks because the anti-vaccs know they can not win with the truth.

Here is the important fact: post vaccination with thimerosal containing vaccines, the mercury levels are still safe.

W&N

AlbusNerdisky
AlbusNerdisky

1 of 2

Mr. Stone, on ethics…and your self-reference to a BMJ rapid response….

1.”Remarkably the first (western) clinical study into the safety of thimerosal was published…”

Fact is there are published “western” studies of clinical safety of thimerosal that predate your posting. Once again the Age of Autism amateur scientists are so staggeringly incompetent they can’t even find the science--much less understand it.

2. “after of months of wrangling the Lancet only admitted the problem of Pichcichero's competing interests”

Your link is ~8.5 years old and nowhere in the correspondence is there anything remotely similar to your claimed admittance of a problem.

This isn’t really surprising since Pichichero exactly followed the Lancet’s disclosure policy--which is still on-line for anyone interested in the truth.

AlbusNerdisky
AlbusNerdisky

Mr. Stone, on science….

1. You still have not posted any words to the effect that our children’s health is so important that we should try we should use actual scientists to help us understand the science,

2. You continue to ignore the examples of how Age of Autism deceives parents by literally making things up about the science they don’t like,

3. You continue to ignore the actual results from the Pichichero paper: mercury levels in children post-vaccination with thimerosal containing vaccines were safe,

4. You respond to the Pichichero data with nothing more than an absurd character attack.

The fact is that Pichichero’s disclosure was perfectly ethical and correct.

The two journals have different policies for what is to be disclosed and in your haste to attack Pichichero’s ethics to didn’t bother to read the disclosure policies. The irony of your profound, 8-year ethical failure is not missed on most people.

W&N

lilady
lilady

@JohnStone Two Age of Autism blogs, eh?

You didn't expose anything with your crank comment on the BMJ Rapid Responses.

Just keep those comments coming, Stone.  I so enjoy your feeble attempts at science.



lilady
lilady

@JohnStoneReally Mr. Stone?  You present as *evidence* the blogs from Age of Autism?

How about commenting on the actual decision of the GMC "Fitness to Practice" hearing?

http://www.gmc-uk.org/Wakefield_SPM_and_SANCTION.pdf_32595267.pdf

Why didn't Wakefield offer any evidence in his defense during that hearing?

Why didn't Wakefield call any witnesses, such as the parents who were referred to him through JABS (that notorious anti-vaccine U.K. group), thence through the attorney who was paying him for his *expert witness* testimony, in the scheme to sue the MMR vaccine manufacturer?

Why did the GMC find that Wakefield ordered dangerous, invasive  and not-medically-indicated medical procedures for some of the children who were part of his *study*.?

Where are those bowel specimens and the original pathology scoring sheets?

Why did David Lewis, Wakefield"s "sludge specialist" hand over to Mr. Deer some bogus hand-written scoring sheets that he *located* in Wakefield's personal files located in the United States?

Why didn't Wakefield appeal the GMC decision?

 






JohnStone
JohnStone

lilady

Part Two

What happened to the specimens? Well we know what happened to the specimens:

http://www.ageofautism.com/2012/11/another-tale-of-the-corrupt-and-bungling-bbc.html

About the Lancet's hidden conflicts and misinformation you can read here:

http://www.ageofautism.com/2010/03/lancet-boss-failed-to-disclosed-own-conflicts-to-parliament-while-denouncing-wakefield.html

Finally, after of months of wrangling the Lancet only admitted the problem of Pichcichero's competing interests, when I exposed them in BMJ Rapid Responses:

http://www.bmj.com/rapid-response/2011/10/30/thimerosal-case-non-disclosure-lancet

JohnStone
JohnStone

lilady

Part One

It is scarcely relevant here but why did the Lancet retract the Wakefield study? Perhaps, because they were liars and bullies (not mention pharma cronies). Anyhow, Wakefield disclosed that he was an expert in the MMR case in May 1998 which he correctly averred had nothing to do with funding of the Lancet paper. The ruling of Mr Justice Mitting in the High Court last year was that there was no problem about how the children were admitted to hospital or to the paper, the paper was not funded by the Legal Aid Board, the children were referred and seen in a proper way, no unauthorised investigations, no inappropriate investigations etc. Walker-Smith, senior author of the paper, was completely exonerated.

http://www.ageofautism.com/2012/04/the-lancet-should-reinstate-the-andrew-wakefield-paper.html

lilady
lilady

@JohnStone More of your libelous smear tactics, Mr. Stone?

Now how about that; the author supplies his history of receiving grants and/or honoraria from pharmaceutical companies, so that he is in compliance with publishing guidelines.  

How about your *hero* the disgraced former medical doctor, who accepted $750,000 USD from the attorney who was setting up a lawsuit to sue the manufacturer of the MMR vaccine?  Do tell us why Wakefield got patient *referrals* from this lawyer...and tell us which anti-vaccine group in the U.K. referred those same patients to the lawyer. How about the two offshore companies that Wakefield set up to manufacture a single antigen measles vaccine and to develop and market testing kits to test for his bogus diagnosis of "autistic enterocolitis".  Wakefield failed to "mention" those monumental Conflicts of Interest. Why?

What happened to the bowel specimens for the 12 children in his study?

Why did the Lancet retract Wakefield's study?

 

 

JohnStone
JohnStone

Hi W&N

Unfortunately, Michael Pichichero seems to have had an attack of amnesia when submitting the paper and forgot to mention his competing interests listed in contemporaneous article (too many flu jabs perhaps?):

"The author has received research grants and/or honoraria from the following pharmaceutical companies: Abbott Laboratories, Inc.; Bristol Myers Squibb Company; Eli Lilly and Company; Merck&Co.; Pasteur Merieux Connaught; Pfizer Labs; Roche Laboratories; Roussel-Uclaf; Schering Corporation; Smith Kline Beecham Pharmaceuticals; Upjohn Company; Wyeth- Lederle."

AlbusNerdisky
AlbusNerdisky

Surprise Mr. Stone--you didn't post the Pichichero paper.

Here it is:

http://www.pkids.org/files/pdf/LANCET.pdf

Where everyone that bothers to read the words can see Age of Autism in action.Fabrications about the Pichichero paper to obscure their fabrications about the Burbacher paper....etc etc.

 Naturally you still haven't posted the major finding from the Pichichero paper:mercury levels in infants post vaccination are safe.

As usual not only have you failed to get the basic English meaning of the words correct, ...you still are yet to post something like: our children's health is important enough to that we should consult with qualified scientists about science.

W&N

JohnStone
JohnStone

W&N

No, this is what Burbacher says:

"More interestingly, the washout blood Hg T1/2 in the thimerosal-exposed infant macaques (7 days) is remarkably similar to the blood Hg T1/2 reported for human infants injected with thimerosal-containing vaccines reported by Pichichero et al. (2002)."

In context he is saying this aspect of his animal study matches closely the result of a study of human infants, which helps to lend plausibility to his own findings. However, Pichichero proposed that all the mercury was rapidly excreted (or relatively rapidly) from the human body and Burbacher showed this was a false assumption. As usual you are citing something out of context.

AlbusNerdisky
AlbusNerdisky

Mr. Stone,

“Silly” would be getting the science used to make important healthcare decisions from the intellectual equivalents of the Keystone Cops.

For example:

http://www.ageofautism.com/2013/01/not-all-mercury-is-toxic-desperate-throw-in-new-scientist-to-prevent-un-ban.html#comments

A particularly silly posting that gets pretty much everything wrong.

One example: “The claim that ethyl mercury is “excreted rapidly”

is based on a study published in the Lancet by Pichichero et al which was disproved by Burbacher et al in 2004”

This is an outright fabrication and in fact the Burbacher paper referenced and explicitly supported the Pichichero paper. But hey, the fabrication fooled all the Age of Autism readers. None of whom cared enough for the truth to bother reading the Burbacher paper.

W&N

MikeStevens1
MikeStevens1

So John, you haven't read the study, but feel qualified to comment on it.

Typical.

JohnStone
JohnStone

W&N

Thank you for making a working link available. It would still be quite unreasonable to infer presently any significance to the correlations in this study, and it cannot help anyone with an autism spectrum condition - it is very hard to imagine how any of it ever could. Unless we are talking about getting rid of people in future with allegedly defective genes.

Otherwise, up to your slippery semantic games as usual - do you know what 'ad hominem' means? Who cares? 

AlbusNerdisky
AlbusNerdisky

Well Mr. Stone,

Since you still haven’t been able to find the paper even when linked to the journals site:

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052239

I guess we shouldn’t be surprised that you don’t understand what ad hominem means, or that you would post something so obviously false as to claim no specifics when there are a number of specific examples posted for all to see.

And naturally you ignored the big picture:

5+ years of Age of Autism posting 100’s of articles on the science of autism…you know genetics, neurology, toxicology, epidemiology….and you still have Zero scientists on staff.

To be very clear, your business model is clearly set-up such that it is impossible for you to get the science correct.

W&N

JohnStone
JohnStone

No specifics - just more ad hominem abuse. For whatever reason the links here for the Hensel study don't work from my computer (from more than one browser). I don't know whether anyone apart from W&N has had more success.

AlbusNerdisky
AlbusNerdisky

Mr. Stone,

Not only is the paper on-line, but the link is in the article above.

Not that it really matters, since your behavior makes your true intentions completely clear.

Fact is your interest is in criticizing vaccines, not in helping our children.

You have, over many, many years, been very clear--you absolutely refuse to even try and get the science correct. Doesn’t matter if we are talking about genetics or neurology of autism, Francis’s comments, or the toxicology of thimerosal--you actively avoid getting the science correct.

This is shameful: our children deserve much, much better.

W&N