Can Aspirin Keep Skin Cancer At Bay?

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The latest study suggests that the popular pain killer can inhibit melanoma.

In the largest investigation of its kind, published in the journal Cancer, researchers found that women who regularly take aspirin have a decreased risk of developing melanoma, and that the protection may be cumulative — the longer they take it, the lower their risk.

More than 61,000 people were diagnosed with skin cancer in the U.S. in 2009, the latest year for which statistics were collected by the Centers for Disease Control (CDC), and deaths from melanoma cost $3.5 billion in lost productivity each year. Despite greater awareness of the dangers of tanning, as well as the importance of protecting sun-exposed exposed skin with clothing or sunscreen, diagnoses of melanoma have inched upward by 2% each year between 2000 and 2009.

(MORE: Can Aspirin Ward Off Skin Cancer?)

In the latest study, the researchers studied 59,806 women between ages 50 to 79 enrolled in the Women’s Health Initiative who were followed for around 12 years. The women answered questions about their medication use, diet and other lifestyle habits such as sun exposure. And even after controlling for skin cancer risk factors such as tanning and low use of sunscreen, the women who reported taking aspirin at least twice a week showed a 21% lower risk of melanoma than the women who didn’t take the pain killer. And the longer they stayed on aspirin, the lower their risk; women who used aspirin regularly for one to four years for example, showed an 11% lower risk of melanoma compared to those who didn’t take the pills for that time, while women who continued taking aspirin for five or more years enjoyed a 30% lower chance of developing melanoma.

How is the pain killer connected to cancer?

The explain could lie with inflammation, the potentially damaging reaction by the immune system to stresses, irritants and foreign intruders such as bacteria and viruses. Since aspirin works to reduce inflammation, it could help to quiet down the processes that can trigger cells to grow abnormally. The study isn’t the first to connect the anti-inflammatory effects of aspirin to a lower risk of developing melanoma, but it is the largest to see a significant pattern among pain killer users. In other studies, aspirin has been associated with a lower risk of other cancers, potentially for the same reason that curbing inflammation may also inhibit tumors. A study published last year linked aspirin and other pain relief drugs like ibuprofen, called nonsteroidal anti-inflammatory drugs (NSAIDs), to a 46% lower risk of colon, lung and prostate cancers. But the current study did not find a protective effect against melanoma for NSAIDs other than aspirin.

(MORE: Aspirin, a Wonder Drug? Studies Show It May Prevent Cancer)

The findings are exciting for the cancer prevention, since aspirin is widely available and inexpensive. But because the study only compared past use to melanoma outcomes, the researchers say the next step in confirming the results would be to conduct a clinical study in which some participants take aspirin on a regular basis and others do not, to test whether the pain killer can prevent melanoma. Any benefits, they say, will have to be weighed against the risks of taking aspirin, which include stomach bleeding and clotting disorders.

“There’ve been about eight studies that have looked at melanoma, and about half of them find slightly lower risk and half find no connection at all. You look at the totality of the evidence, and right now it’s rather mixed,” Eric Jacobs, an epidemiologist at the American Cancer Society told NPR.

Until the data on aspirin and skin cancer is solidified, he and other cancer experts recommend avoiding tanning beds, using sunscreen with SPF above 15 and finding shade and covering up when in the sun in order to lower  chances of developing skin cancer.

6 comments
jjssmith1982
jjssmith1982

Aspirin has truly become the wonder drug of our time even though it is more than 100 years old. The latest findings about this humble drug being able to prevent so many cancers in the human body, including skin cancer, is truly amazing. It seems that often we should look at the cures that science has already given us rather than to always look for newer ones.

Melanoma_Research_Foundation
Melanoma_Research_Foundation

This is very interesting and provocative study, and builds on work reported last year.Still, we don’t yet have the evidence to tell us what this information means for people or why aspirin would have an impact on melanoma incidence. What we *do* know is that the majority of melanoma cases in the United States are tied to UV exposure and that nothing suggests taking aspirin replaces a good, common sense decision to reduce your UV exposure. 

Sun safety is critical in preventing a melanoma diagnosis. This means skipping the tanning bed, wearing at least SPF 30 sunscreen, UV protective clothing and checking your skin. Looking for any changes in your moles can mean an early catch that can save your life.

The Melanoma Research Foundation, www.melanoma.org.

bojimbo26
bojimbo26

And when it's prescibed for high blood pressure ? ( I'm male by the way ) .

DarylBrunt
DarylBrunt

I personally do not agree with anything regarding skin cancer. Why? Because I studied Science at school and I remember things. In my "un"learned opinion skin cancer is actually a consequence of sun light avoidance. The human body has been in the sun for hundreds and thousands of years...right up until when? someone thought that they couldnt handle a little burn. So there are 2 trains of Science thought; either we are evolutionary which means ADAPTIVE or we are made by God. So either way the body will adapt. When I was born, I was olive. After consistent avoidance of the sun I basically went white. When I decided to tan I found that I burnt, however after a few years of controlled burning/tanning my body DECIDED it was time to actually TAN and now rather than burn, I am olive again. Cancer is a consequence of CELLAR distress. Our diets and lifestyles and lack of sleep and smoking and bad water ALL add to this distress, thus it is rather easy for Skin Cancer to exploit all the holes we left. Binge TANNING causes skin cancer. Consistent exposure to the sun actually causes a physiological change for the next generation. White English who moved to Australia and burn red have BROWNER children. Go look at the US and Australian beaches...basic science and adaptation

CharlesEAkers
CharlesEAkers

Long term aspirin use leads to blindness.  This research result was not mentioned in the article.  
There are much better ways of dealing with inflammation than aspirin.