Anti-HIV Antibodies May Spur AIDS Vaccine Development

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Illustration of HIV (Human Immunodeficiency Virus) capsids with protruding docking (gp120) and transmembrane (gp41) glycoproteins

Researchers report a breakthrough in generating powerful antibodies that can neutralize HIV.

An HIV infection is really an intensive molecular arms race launched from the minute the virus infects a new host. AIDS progresses not because the body isn’t capable of fighting off HIV – it is. But the immune defenses eventually succumb to the virus in the final standoff. Now researchers, led by Barton Haynes, director of the Duke University Human Vaccine Institute at Duke University School of Medicine, believe they have found a way to tip the odds in the immune system’s favor.

From the moment of infection, the immune system goes on alert and immediately generates antibodies designed to attach to and destroy HIV. And for the first few weeks, these antibodies are successful, eliminating all but a few viruses that remain hidden away from the body’s surveillance systems. These viral stalwarts then mutate to escape detection and start to flourish, expanding until new antibodies are generated to dispatch them. That launches another wave of viral destruction that pushes HIV to mutate yet again, prompting another immune attack, and so on, until eventually the body isn’t able to keep up with the virus and pushes out poor, or no more additional antibodies that can neutralize HIV.

(MORE: A Newborn May Be Cured of HIV. Is the End of AIDS Near?)

That’s the scenario in about 80% of those who are infected with HIV. But in a fortunate 20%, this arms race is stacked in the host’s favor, with antibodies that are able to neutralize not just the latest, specific mutated version of HIV but a broader range of viral marauders. Such broadly neutralizing antibodies are the holy grail of AIDS vaccine researchers, who hope to corral these agents in an immunization that can protect against infection.

But most attempts to convince the body to churn out these antibodies haven’t been successful, primarily because the antibodies take on an unusual shape that marks them for destruction by the very immune system that generated them. In addition, these antibodies can bind to and destroy healthy cells as well as HIV-infected ones, making them a potentially useful but unpredictable partner in fighting the virus.

(MORE: Study Explains How the First Effective HIV Vaccine Worked)

But by carefully mapping the different mutations that HIV generates, and the resulting antibodies made against them in an African patient who is able to produce broadly neutralizing antibodies, Haynes and his colleagues believe they have come up with a way to drive the immune system to preferentially churn out these HIV-fighting immune cells. “We followed individuals from the time of HIV infection to the time they generated broadly neutralizing antibodies, and mapped and isolated the virus at every step along the way so we now don’t have to guess any more about what induced those antibodies. We have a map on how to recreate the sequential [versions of HIV] that could drive particular antibody lineages.”

The work, which was published in the journal Nature, was possible because Haynes had collected and saved blood samples over the course of about three years from roughly 400 patients, starting within weeks of their infection. Researchers found that the first round of broadly neutralizing antibodies generally appeared about 14 weeks after infection, and these were better able to bind to portions of HIV that the virus doesn’t change as quickly or as frequently. That makes the antibodies useful weapons in attacking the virus’s Achille’s heel, and a potentially powerful target for an effective vaccine.

(MORE: Treatment As Prevention: How the New Way to Control HIV Came to Be)

“Now we have a picture of how these antibodies developed, so what we are doing is figuring out how to use them to make a vaccine,” says Haynes.

The challenge will be to push the body to pump out these antibodies rather than the more specific ones aimed at the ever-changing portions of HIV. It turns out that most infected people do produce these antibodies, but HIV distracts the immune system into crowding them out with all the subsequent iterations they convince the body to make against the mutating virus. “We are trying to take an unusual or rare event and make it more common,” says Haynes.

(MORE: HIV Drugs May Prevent Infection in Healthy Individuals)

Ultimately, he adds, a vaccine will probably need to generate several of these broadly neutralizing antibodies; each person tends to make unique versions that have differing efficacy in stopping HIV. But there’s precedent for such an approach, since the antiretroviral drugs that now control HIV infections are used in combination to hit the virus at more than one point in its life cycle. “The hope is that by mapping individual pathways to generating broadly neutralizing antibodies, we can find some commonalities among people even though everyone is different, and that gives us hope for using these pathways in a vaccine,” says Haynes. “It’s a huge effort but it looks like it’s going to pay off.”

7 comments
JosePatrich
JosePatrich

this is a testimony i have been HIV positive for over 8years when i had to contact my brother who lives in Africa and asked him if i can find some one that can cure HIV he told me that they is a herbalist in the country who gives the cure for free and he gave me the email of the herbalist and which i emailed him and he told me not to worry and gave me the concoction which i took for over two weeks and after i finished i when to the hospital for a test and after the results i was found free i had to travel over to go and meet him to thank him for the good thing he has done to me and my family don't forget to check on him this is his email DR.OLUBAMSPELLHOME@GMAIL.COM or DR.OLUBAMSPELLHOME@LIVE.COM you can contact him any time and you shall be free .

JosePatrich
JosePatrich

My Name is jenny from uk. i decided to share my life testimony on this forum because i know so many people will have same problem which you are finding difficult to solve. i have been sick for over 2 years now. the doctor could not even find the name of the sickness.their was an object moving inside my body, and my body was always hot. i have been to so many hospitals and i could not get the solution to my sickness. i decided to discuss my problem with my friend Mrs Cynthia. she introduce me to a herbalist. i never believe i could get healed so fast, she gave me the email of the herbal Doctor by name Dr olubam. i contacted him via email: email: DR.OLUBAMSPELLHOME@GMAIL.com i contacted him and he assure me that he will help me cure the sickness. he instructed me on what to do and i obeyed him. to my greatest surprise, i was healed within three days. i have promise to share it to the world the great work do for me by Dr olubam. if you have any sickness that you need cure as fast as you think. i would advice you to contact Dr olubam via email email: DR.OLUBAMSPELLHOME@GMAIL.com DR.OLUBAMSPELLHOME@LIVE.COM he will help you cure your sickness just the way he have help me.

Camilaluke
Camilaluke

i will thank Mrs lucia for letting the world knows the powerful man that help her from AIDS disease. This was what i have all my life been waiting for since i was infected by HIV last 6 months. I always spend money for drugs always but still yet my weight becomes poorer and my joint always getting painful and inching all day. But when i met this comment last 3 days, i quickly contacted Dr.olta the Traditional helper. He is from the western part of Africa, i didn't spend much as i spent for drugs each day, and i for the fact truly reason this because my life was already as take by this disease called AIDS. Truly, when it was 9:00 clock on Monday this week he called me that his oracle urgently required some few life items to enable the disease wipe out successfully, then i was asked to send down 200 usd ($). Which i did. He truly bought the items and surprisingly, yesterday afternoon Dr.olta called me that my work has been finally done and it work out well. I was glad and he told me to rush down to my hospital for checkup. Which i really did, my brothers and sisters i went down crying because no one has ever done this to a person in life. Dr.olta truly healed me. I was crying it was a dream to my eyes when the doctor said to me that I am HIV NEGATIVE. I am now a free born in life, am now like other people who now think things like human. For these days and forever, i will accept Dr.olta as my father and my healer and helper. He is a great man. Thank you sir. I know i cant reward you. But my God in heaven can. Thank you sir once again.

Regards.

Email him now for your problem solve at:( spelldoctor3@gmail.com)or call +2347053443408

Frank234
Frank234


DR Ekpiku is the only Dr who could ever get my HIV-AIDS cured with his healing spell, i have tried almost everything but i could'nt find any solution on my disease, despite all these happening to me, i always spend alot to buy a HIV drugs from hospital and taking some several medications but no relieve, until one day i was just browsing on the internet when i come accross a great post of !Michelle! who truly said that she was been diagnose with HIV and was healed that very week through the help of these great powerful healing spell doctor, sometime i really wonder why people called him Ekpiku the great, i never knew it was all because of the great and perfect work that he has been doing that is causing all this. so i quickly contacted him, and he ask me some few questions and he said a thing i will never forget that anyone who contacted him is ! always getting his or her healing in just 6 hours after doing all he ask you, so i was amazed all the time i heard that from him, so i did all things only to see that at the very day which he said i will be healed, all the strenght that has left me before rush back and i becomes very strong and healthy, this disease almost kills my life all because of me, so i will to hospital to give the final test to the disease and the doctor said i am HIV negative, i am very amazed and happy about the healing Dr Ekpiku gave to me from the ancient part of africa, you can email him now for your own healing too at: Ekpikuspelltemple@live.com

AsoOiriroko
AsoOiriroko

i want to thank dr oririoko for the herbal hiv medicine he gave to me and my daughter, i was suffering from hiv when i gave birth to my daughter and that was how my daughter got the sickness indirect from me, but to God be the glory that i am healed with the herbal medicine that DR Oko gave to me when i contacted him. i want to use this medium to tell everyone that the solution to our sickness has come, so i will like you to contact this great healer on his email address: droririokohelphome@gmail.com with him all your pains will be gone, i am really happy today that i and my daughter are cured of hiv, we are now negative after the use of his medicine,my doctor confirm it. and i was not change for the treament he gave me. you can contect me on my email mrsjaneworld@gmail.com for more information about him.

once more i say a big thank to you Dr oririoko for your healing hands upon my life and my daughter, i say may God continue to bless you abundantly and give you more power to keep helping those that want your help in their lives. email him now he is waiting to receive you.

once  again his email droririokohelphome@gmail.com


Herlina
Herlina

hello everyone, HIV CURE IS OUT BY PROPHET OLORUN
I don't just know the reason why some people is finding it difficult to believe that there is a cure for hiv, I have been hiv+ since last three years with my girlfriend but today I am happy that I am hiv_ with herbal medicine of Dr Olorun the great healer, i was browsing the internet searching for help when I came across a testimony shared by someone on how Dr Olorun cure his hiv I was so much in need of getting his treatment but after all Dr Olorun brought a smile to my face with his herbal medicine. I am so much happy today that we have someone like this great healer out there, so my people out there kindly contact this great healier on his email address: Olorunoduduwaspiritualtemple@gmail.com, please sir keep your good work cause there are people out there who is in need of your healing medicine.once more contact him now: Olorunoduduwaspiritualtemple@gmail.com or call him on +2348165219949

drscgarg
drscgarg

Using patients own blood sample and used as auto vaccine can stimulate antibody formation which can be instrumental in enhanced antibody formations which could be ameliorative or curative for HIV infections . The enhanced responses have been learned and studied through contemporary/ allied medical practices. when no extraneous material is used in the procedure and as such being ethical