Antidepressants Linked To Higher Risk of Complications After Surgery

  • Share
  • Read Later
Photo Researchers / Getty Images/Photo Researchers RM

The most popular class of drugs used to treat depression, the selective serotonin reuptake inhibitors (SSRIs), may increase risk of bleeding and the need for blood transfusions following operations, according a study.

Previous studies have investigated the dangers of SSRI use among pregnant women and possible associations with suicide among adolescents, but the latest study looked into evidence that correlated SSRIs, which include fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil),  with an elevated risk of bleeding and irregular heart beats in patients who were hospitalized for surgery.

The researchers from the University of California, San Francisco took a closer look at SSRI use before surgery and the rate of adverse events in a group of 530,416 patients over age 18 who had operations between January 2006 through December 2008 at 375 different U.S. hospitals.

(MORE: The Pros and Cons of Antidepressant Use During Pregnancy)

They analyzed reports of bleeding, transfusions and irregular heart functions during surgery, as well as how long the patients stayed in the hospital. Patients who were taking SSRIs before their operations had a greater risk of bleeding, were more likely to be re-admitted within a month following their procedures, or were more likely to die during the study period than those who were not taking the antidepressants.

To determine whether the effect was due to the medications themselves, or to some other factors shared by the patients taking antidepressants, the scientists adjusted for the potential contribution that depression, age, gender and the condition requiring surgery in the first place might have had on the risk of bleeding and potentially fatal complications. Even after controlling for these factors, the correlation between SSRI use and the higher risk of adverse events remained.

Previous studies suggest that the connection might make sense, since SSRIs prevent nerve cells in the brain from reabsorbing the hormone serotonin, and serotonin can interfere with the function of platelets that are critical for helping blood to clot properly.

It’s still possible, however, that additional factors that the researchers have not yet considered could explain the association; the patients taking SSRIs, for example, were more likely to be obese or have respiratory conditions, which could independently affect risk of complications after surgery. Other analyses also showed that patients who took SSRIs were more likely to experience chronic pain and damage to the peripheral nerves — all of which are linked to a higher likelihood for hospital readmission and mortality.

(MORE: New Research on the Antidepressant-vs.-Placebo Debate)

Because of the increased risk, whatever the cause, some hospitals now recommend [PDF] that patients using the drugs stop taking them for about two weeks or more before a scheduled surgery. The study wasn’t designed to determine the optimal period of time that patients should stay off their medications to avoid complications, but the results point to the need for more research to investigate the link. “Given the ubiquitous nature of SSRIs in U.S. health care and the potential risks of proceeding without adequate evidence for a strategy on how to mitigate risks of perioperative SSRI use, any study costs would seem money well spent,” the authors write.

The study is published in the journal JAMA Internal Medicine.

57 comments
aileen123
aileen123

hand clap, a drum smash, a squawk on an instrument, usually a quite short burst of sound — to determine what the so-called sonic envelope in that space would do to those sounds.
volo milano cuba

etssanjeev
etssanjeev

If you routine ones proceed with a appropriate, dependable, skilled, covered, listed, licensed and proficient packers along with movers after that it is selected you will get some sort of comfort with your proceed. You'll not want to do everything. All responsibilities related to go will probably be accomplished completely by means of skilled specialists.

Packers and Movers Pune @ http://www.top8list.in/packers-movers-pune

Packers and Movers Bangalore @ http://www.top8list.in/packers-movers-bangalore

Packers and Movers in Delhi @ http://www.top8list.in/packers-movers-delhi

etssanjeev
etssanjeev

Time period saving, suitable packing, full guidance, peace-of-mind, hassle-free & protected execution involving overall practice, risk-free & damage-free transportation of items, guidance inside launching & unloading course of action and the like are usually many important advantages of using professional packers and also movers as well as going businesses.

Packers and Movers Gurgaon @ http://www.top8list.in/packers-movers-gurgaon

Packers and MoversNoida @ http://www.top8list.in/packers-movers-noida

Packers and Movers @ http://www.top8list.in

AfiaKhan
AfiaKhan

Your blogs further more each else volume is so entertaining further serviceable It appoints me befall retreat encore. I will instantly grab your rss feed to stay informed of any updates.pascal wisniec

AfiaKhan
AfiaKhan

After reading your article I was amazed. I know that you explain it very well. And I hope that other readers will also experience how I feel after reading your article. I feel very grateful that I read this. It is very helpful and very informative and I really learned a lot from it.cashland cash advance

AfiaKhan
AfiaKhan

Thank you for your post, I look for such article along time, today i find it finally. this post give me lots of advise it is very useful for me.mycashnow

AfiaKhan
AfiaKhan

It's really nice and meanful. it's really cool blog. Linking is very useful thing.you have really helped lots of people who visit blog and provide them usefull information.this site

aileen123
aileen123

Friendship is like a box of crayons , each has a different color , but try when combined . They will show you the colors are beautiful like a rainbow . Jetzt ansehen

aileen123
aileen123

Similarly, the only way to substantively move the practice of architecture forward is to establish practice methodologies based on solid, scientific evidence rather than intuition and anecdote.
girlsdoporn

AfiaKhan
AfiaKhan

We offer the fastest Illinois license plate sticker renewals in the state. We are tied directly into the sate’s renewal database which allows us to process your request almost instantly.healthraport

AfiaKhan
AfiaKhan

A good blog always comes-up with new and exciting information and while reading I have feel that this blog is really have all those quality that qualify a blog to be a one.I wanted to leave a little comment to support you and wish you a good continuation. Wishing you the best of luck for all your blogging efforts.junk removal service queens

AfiaKhan
AfiaKhan

While I have to disagree on some of the information, however I still really liked it. I look forward to viewing more of your posts. women s tuxedo suits

AfiaKhan
AfiaKhan

Very informative post ! There is a lot of information here that can help any business get started with a successful social networking campaign !pakistani cakes

AfiaKhan
AfiaKhan

I most likely appreciating each and every bit of it. It is an incredible site and decent impart. I need to much obliged. Great employment! You all do an incredible blog, and have some extraordinary substance. Keep doing awesome.low down payments on used cars in houston tx

AfiaKhan
AfiaKhan

Because when you write a book then at least on selling a book you get a percentage. Thank you and good luck on informing people more about it…used smart car houston

AfiaKhan
AfiaKhan

I am a new user of this site so here i saw multiple articles and posts posted by this site,I curious more interest in some of them hope you will give more information on this topics in your next articles. business cash advance in manhattan

aileen123
aileen123

Your content post has excellent value to perform right with sensible marks from the timed actions on the loyal things to produce the same level high.
bubblegum casting

aileen123
aileen123

his site while searching for work-form-home options. I found Hubwit as a transparent site, a social hub which is a conglomerate of Buyers and Sellers who are ready to offer online digital consultancy at decent cost.
girlsdoporn

aileen123
aileen123

the application. Keep away from products that say "volumizing," which includes ingredients such as rice & wheat. Every woman must have a couple of fundamentals. Everyone needs slacks, hemmed pair of denims for heels & for sneakers

https://rebelmouse.com/diabetesmiraclecurereviews

aileen123
aileen123

While I have to disagree on some of the information, however I still really liked it. I look forward to viewing more of your posts. girlsdoporn

AfiaKhan
AfiaKhan

Once I thought about things like: why such information is for free here? Because when you write a book then at least on selling a book you get a percentage. Thank you and good luck on informing people more about it…Γυναικεία Παπούτσια

AfiaKhan
AfiaKhan

This post is really magnificent. I really like this post. It is one of the best posts that I’ve read in a long time. Thanks a lot for this really good post. I really appreciate it!amway opinie

AfiaKhan
AfiaKhan

Once I thought about things like: why such information is for free here? Because when you write a book then at least on selling a book you get a percentage. Thank you and good luck on informing people more about it…amway opinie

AfiaKhan
AfiaKhan

Regular visits listed here are the easiest method to appreciate your energy, which is why why I am going to the website everyday, searching for new, interesting info. Many, thank you!darmowe rozmowy na stacjonarny

AfiaKhan
AfiaKhan

Pretty good post. I just stumbled upon your blog and wanted to say that I have really enjoyed reading your blog posts. Any way I’ll be subscribing to your feed and I hope you post again soon.Locksmith Near Me

AfiaKhan
AfiaKhan

You're in point of fact a just right webmaster. The website loading speed is amazing. It kind of feels that you're doing any distinctive trick. Moreover, The contents are masterpiece. you have done a fantastic activity on this subject!

brad pitt suit

AfiaKhan
AfiaKhan

wow, great, I was wondering how to cure acne naturally. and found your site by google, learned a lot, now i’m a bit clear. I’ve bookmark your site and also add rss. keep us updated.houston cakes

AfiaKhan
AfiaKhan

Pretty good post. I just stumbled upon your blog and wanted to say that I have really enjoyed reading your blog posts. Any way I’ll be subscribing to your feed and I hope you post again soon.used cars for sale in houston

AfiaKhan
AfiaKhan

I like viewing web sites which comprehend the price of delivering the excellent useful resource free of charge. I truly adored reading your posting. Thank you!car warranty

AfiaKhan
AfiaKhan

I don’t have the time at the moment to fully read your site but I have bookmarked it and also add your RSS feeds. I will be back in a day or two. thanks for a great site.houston car dealerships

AfiaKhan
AfiaKhan

I feel really happy to have seen your webpage and look forward to so many more entertaining times reading here. Thanks once more for all the details.used cadillac houston

AfiaKhan
AfiaKhan

Truly, this article is really one of the very best in the history of articles. I am a antique ’Article’ collector and I sometimes read some new articles if I find them interesting. And I found this one pretty fascinating and it should go into my collection. Very good work!yishun new launch

AfiaKhan
AfiaKhan

I’m excited to uncover this page. I need to to thank you for ones time for this particularly fantastic read!! I definitely really liked every part of it and i also have you saved to fav to look at new information in your site.παπουτσια μπαλαρινεσ

AfiaKhan
AfiaKhan

Pretty good post. I just stumbled upon your blog and wanted to say that I have really enjoyed reading your blog posts. Any way I’ll be subscribing to your feed and I hope you post again soon.online pet store

AfiaKhan
AfiaKhan

Wow! Such an amazing and helpful post this is. I really really love it. It's so good and so awesome. I am just amazed. I hope that you continue to do your work like this in the future also.jewelry online shopping

AfiaKhan
AfiaKhan

Truly, this article is really one of the very best in the history of articles. I am a antique ’Article’ collector and I sometimes read some new articles if I find them interesting. And I found this one pretty fascinating and it should go into my collection. Very good work!steve harvey suits

AfiaKhan
AfiaKhan

I most likely appreciating each and every bit of it. It is an incredible site and decent impart. I need to much obliged. Great employment! You all do an incredible blog, and have some extraordinary substance. Keep doing awesome.luxury auto sales

AfiaKhan
AfiaKhan

I feel really happy to have seen your webpage and look forward to so many more entertaining times reading here. Thanks once more for all the details.cadillac dealership houston

AfiaKhan
AfiaKhan

I would just like to say that, after reading the full study, you did an excellent job summarizing and making it accessible to the average reader. Thank you for the well-written article! rebelmouse.com