Family Matters

Hard Choices Angelina Jolie Faces About Testing Her Kids for Breast Cancer Genes

The actress made the difficult decision to remove both her breasts before she developed breast cancer, but her genetic makeup means her children may be at increased risk of the disease as well.

  • Share
  • Read Later
Jun Sato / WireImage

Angelina Jolie and Brad Pitt with their kids in 2011

Most women who get breast cancer each year have no family history, but Angelina Jolie’s story was different. Her mom died at age 56 of ovarian cancer, a related disease.

Doing her best to make sure that her own six kids don’t lose their mother to breast cancer motivated Jolie to have a preventive double mastectomy, a process she revealed in a bold and candid op-ed in Tuesday’s New York Times.

We often speak of “Mommy’s mommy,” and I find myself trying to explain the illness that took her away from us. They have asked if the same could happen to me. I have always told them not to worry, but the truth is I carry a “faulty” gene, BRCA1, which sharply increases my risk of developing breast cancer and ovarian cancer.

As a BRCA1 carrier, Jolie stands a 50% chance of having passed the faulty gene to each of her three biological children. While that possibility can provoke tremendous anxiety in parents, most experts don’t recommend childhood genetic testing for diseases like breast cancer that don’t often affect young children. “In a typical situation, most people would counsel her to wait until her biological children are mature adolescents or young adults before discussing this with them,” says Dr. Robert Green, a medical geneticist at Harvard Medical School. “But given that she’s a public figure, it’s going to be harder to shield them.”  

(MOREWill My Son Develop Cancer? The Promise (and Pitfalls) of Sequencing Children’s Genomes)

In February, both the American Academy of Pediatrics (AAP) and the American College of Medical Genetics and Genomics (ACMG) recommended against testing a child for adult-onset diseases such as breast cancer. However, the experts who developed the statements told TIME that if parents insist on testing their kids, they should be allowed to proceed:

While the earlier statements from the AAP and ACMG firmly advised against genetic testing in children to determine future risk of disease, the updated policy acknowledges that parents are the ultimate decision-makers when it comes to childhood-onset conditions. Predictive genetic testing for adult-onset conditions is still strongly discouraged, but in rare cases, if the parents are in agreement — and, ideally, the child is old enough to concur — testing can be ordered.

“If the family truly believes this is what’s best for the child, we need to respect that,” says Dr. Lainie Friedman Ross, a professor of pediatrics and clinical ethics at the University of Chicago and the statement’s lead author.

Historically, the medical community has been reluctant to test kids for fear of causing psychological harm: could the knowledge that kids are going to get sick affect family bonding? Would mom and dad treat the affected child differently from his siblings or fall into the trap of the “vulnerable child” syndrome, becoming so nervous about a child’s health that they don’t let him out of their sight? “We still worry about that, but we’ve come to realize to the extent that there are data that the concerns were probably over-hyped,” says Ross.

The rationale behind not testing kids for breast cancer takes into consideration that many adults who suspect they may have a BRCA1 or BRCA2 mutation — two known gene changes that increase the likelihood of developing breast and ovarian cancer — ultimately decide not to get tested.  “There is a long-standing consensus reaffirmed earlier this year that there should be a presumption against doing these tests in children,” says Dr. Ellen Wright Clayton, a pediatrician and co-founder of the Center for Biomedical Ethics and Society at Vanderbilt University. But, she notes, it’s an “uneasy consensus.”

(MOREDo All Women Need Genetic Testing Before Pregnancy?)

“There’s no medical benefit to doing this in childhood,” says Clayton. “Parents are supposed to shape their child’s future — that’s their job — but testing forecloses choice in a setting where we know that when given a choice, lots of adults forego getting tested.”

As genomic tests grow increasingly sophisticated, parents could potentially find themselves faced with the prospect of being blind-sided by genetic results they hadn’t anticipated. Say a sick child has her genome sequenced and test results reveal both the cause of her illness and the unexpected knowledge that she has an unrelated genetic mutation that puts her at increased risk of other diseases. “If you’re looking in the area of chromosome 17 and BRCA1 is nearby, you can’t ignore it,” says Barbara Bowles Biesecker, director of the genetic-counseling program at the National Human Genome Research Institute, told TIME last year in a series of articles about the implications of sequencing children’s genomes. “What are you going to do, put blinders on and not look to the left?”

(MORE: ‘Both My Sons Deserve to Live’: A Mother’s Plea for Quicker Action from the FDA)

Yet even some women who have beaten breast cancer have decided that knowing about their own children’s risk is probably not a good idea. Breast-cancer survivor Debbie Horwitz, a Raleigh, N.C., mother of two young kids, learned a few years ago that she inherited a breast-cancer mutation from her mother, who died of the disease. She was set on testing Jordan, her then-newborn daughter, but bowed to her husband’s insistence that it made little sense. “I don’t think it’s fair for us to have that information now and have that heaviness in our family or in how we relate to Jordan,” Horwitz said in the series. “I think knowing whether Jordan is positive or negative would also cause a lot of tension and sadness in our family.”

Jolie didn’t delve into her thoughts or worries about passing on a legacy of breast cancer. But it’s a good bet that she will be wrestling with the same difficult decisions about whether — and when — to broach the topic of testing her children for BRCA mutations. Knowing our genetic history is becoming an increasingly important part of conversations we have with our doctors about our health. And that dialogue will inevitably influence the decisions we make about how we choose to treat disease.


If I had the mutation or I should say my wife had the mutation I would absolutely have my kids tested. 


No child should be tested.... that should be his/her personal, individual decision once s/he reaches adulthood. And by then, the situation may have changed enough to make the testing either routine with clearly defined options for followup or unnecessary. 


One might wonder whether this gene defect responds the same as other gene defects.
Scientists have shown when a faulty gene runs into iron , then , it manifests.
"Scientists discover how iron levels and a faulty gene cause bowel cancer".
"Mice with a faulty APC gene fed a diet low in iron did not develop bowel cancer".

Or even just oxidation / free radicals.
"Current knowledge supports the likelihood that interactions between the primary genetic defect and disruptions in the normal production of free radicals contribute to the pathophysiology of muscular dystrophies"


Dear Time Magazine..

In light of international interest on Angelina Jolie's cancer threat, please share with your public the enclosed peer reviewed work by
US National Academy of Sciences Dr. Campbell and Dr. Esselstyn chief of breast surgery at the Cleveland Clinic's work of over 30 years.

This is a less radical than double mastectomy.  Genes do not become expressed, unless they are aggravated. Our western diet shows average 60- 90 grams of protein, which  encourages cancer growth. For a 70 kilo man no more than 15 grams of protein  and for a woman of 60 kilo s about 12 grams per day are sufficient thus preventing  gene expression that devastates  health.

If they have already the disease, in addition to  conventional treatments, this plant based diet must be adhered  for the rest of the patient's lives.

In the US, it can be seen for free in :

Internationally, there is a trailer with introduction of US Surgeon General and Mrs. Michelle Obama   at:

This is not only important due to health matters, but for economic reasons. All developed nations highest expense is in health care, and preventing this, would save trillions of funds, so more education  and restoration of our  society and planet can be used, thus creating jobs.

Dr. Gabriela Kaplan MD


“The innate capacity to repair damaged DNA seems to affect a woman’s chance of developing breast cancer.”
“Deficient DNA repair appears to triple the risk of breast cancer, researchers have found.”

They’ve tested a common substance found in plants.
“Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair.”