The Angelina Effect: TIME’s New Cover Image Revealed

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TIME Magazine Cover, May 27, 2013
Photograph by Melodie McDaniel / Trunk Archive

Angelina Jolie has never lacked for influence. When she adopted a baby from Ethiopia, inquiries at U.S. adoption agencies about other Ethiopian orphans doubled. When she named other children Vivienne or Maddox, those names shot up the popularity charts for American newborns. So this week, when a woman known for her powerfully iconic beauty announced that she had undergone an elective double mastectomy to reduce her genetically high risk of breast cancer, it was a cultural and medical earthquake — a revelation so arresting it became the subject of TIME’s newest cover story (visit time.com/angelina to read the story; free for subscribers or purchase a digital pass.

Jolie, by nearly universal agreement, made the right choice for her. She tested positive for the breast-cancer-related BRCA1 gene, putting the probability that she would develop the disease at a terrifying 87%; after her surgery, her doctors put that number at just 5%. But a lot of experts worry that we may overread the lessons. Genetic screening is a young science, and while we may have detected genes linked to a host of ills — Alzheimer’s disease, prostate cancer, rheumatoid arthritis, diabetes, heart disease — we often do a terrible job of calculating our resulting risks. Just over one-tenth of 1% of all women carry the same BRCA mutation Jolie has, and yet doctors expect a stampede of women requesting the test. In the U.S., 36% of women who test positive opt for preventive mastectomy, but some doctors argue that regular MRIs and other screening tests may be sufficient to detect the disease, and that less radical procedures, like lumpectomies, may be sufficient to treat it if it does occur.

(Read Cover Story on The Angelina Effect, Why Her Mastectomy Raises Key Issues About Genes, Health and Risk)

Similar misunderstanding of risks is common in the case of prostate cancer too. The familiar PSA screening test detects blood antigens related to the disease, but levels of the marker can rise as a result of inflammation, infection and even riding a bicycle. Still, many men who test positive begin a cascade of subsequent tests and treatments that can often lead to a radical prostatectomy, sometimes with no real sign that they have the disease, or at least not a slow-growing case they could live with.

Human beings are very good at worrying — it’s what keeps us alive and out of harm’s way. But we’re also good at overworrying, making irreversible decisions to reduce or avoid risks that don’t really exist at all. Jolie’s brave example can make us all smarter and help keep us all healthier — but only if we take the right lessons from it.

Click here to read the full story on The Angelina Effect: Why Her Mastectomy Raises Key Issues About Genes, Health and Risk, available exclusively for TIME subscribers.
 
Not a subscriber? Click here to subscribe or purchase a digital access pass.
58 comments
torontofreedating
torontofreedating

Many women had undergone an elective  mastectomy to reduce the genetically high risk of breast cancer, especially after they tested positive for the breast-cancer-related BRCA1 gene. However, as far as i know the screening tests are not very accurate so that's a risk the patient takes. I guess a test should also be done after the tissue is removed to look for signs of cancer. http://www.torontofreedating.com/

v.shapoval.molbio
v.shapoval.molbio

Angelina Jolie ignores Ferromagnetic Cancer Theory (Theory from The Old Testament). According to this theory, any cancer is a subtle iron disease. Any human cell should be interpreted as a society of dia-, para-, superpara-, ferri- and ferromagnetic nanoparticles. Normal breast cells are cells with NON-NUMEROUS intracellular superparamagnetic, ferrimagnetic and ferromagnetic nanoparticles (breast cancer cells - with NUMEROUS). Breast cancer should be interpreted as intracellular superpara-ferri-ferromagnetic ‘infection’. Any intracellular superparamagnetic, ferrimagnetic or ferromagnetic nanoparticle produces an invisible area of influence around itself. When DNA or chromosomes come close to this region of space, they feel a pull or a push from the magnetic nanoparticle. Thus, DNA and chromosomes get defects and disruptions. Breast cancer is a genetic and chromosomal chaos. Cancer researchers invented a very strange BRCA1-gene/breast-cancer theory. Jolie’s mother died of breast cancer in 2007; Jolie’s aunt died of breast cancer in 2013 because Jolie’s family has an imperfect iron metabolism (the set of chemical reactions maintaining homeostasis of iron). Over 4000 human diseases are caused by single gene defects. Genetic disorders may also be complex, multifactorial, or polygenic, meaning they are likely associated with the effects of multiple genes in combination with lifestyles and environmental factors. Breast cancer can be inherited multiple-genetically and multifactorially. Iron is a well-known carcinogen. Oncologists can successfully destroy breast cancer by non-complicated anti-iron methods of The Old Testament. Anti-iron intratumoral injections [sulfur (2%) + olive oil (98%); 36.6C - 39.0C] (by CERAMIC needles) can suppress any tumors and large metastases. Anti-iron accurate slow blood loss (even 75%) [hemoglobin control], anti-iron goat’s milk diet and anti-iron drinking water containing hydrogen sulfide can neutralize any micro-metastases. Cancer researchers (who can't understand Iron Conception / Ferromagnetic Cancer Theory) can treat their daughters and mothers by 'iron surgery' (steel scalpel blades), chemotherapy, radiation and hormone blocking therapy.http://www.medicalnewstoday.com/opinions/98171/;http://healthland.time.com/2011/07/13/almost-every-type-of-cancer-kills-more-men-than-women-study-shows/;http://healthland.time.com/2013/05/15/the-angelina-effect-times-new-cover-image-revealed/;Together We (TIME, Medical News Today and Shapoval) Will Beat CANCER.

SET
SET

Jeffrey Kluger & Alice Park...

In your headline you use the term, "Preventive Mastectomy."  She had a prophylactic mastectomy.  There is a difference.  As of yet, there is no "Preventing" cancer -- there is doing everything possible to reduce risk.  Your headline is totally misleading and false and serves to add to the confusion and misinformation that surround this deadly disease.

Sherm
Sherm

Angie is the greatest human to ever live.  We should start a new religion to spread her teachings to all people:  Angieanity.

ravenaver
ravenaver

I doubt Angelina made this decision lightly. Given that her appearance is a huge part of what has made her career she has probably had to think this through in more ways than someone who is not an actress or from some other image based career would. She is clearly aware that this only reduces her risk and does not completely eliminate it. It goes from something like an 87% risk to about a 5% risk, if what I read has their facts straight. So what if she had an experimental and depressed phase to her life, many of us have. It is just that most of us don't have it publicized to the whole world. For her to come through that, especially while in the limelight, and become the woman she has become, working with the UN, creating the beautiful loving family she has with Brad, and standing strong in her decision to be as healthy for as long as she can for her family says nothing about her other than pure courage, compassion and grace. From all that I see about her, she is a woman to look up to.

megutierrez74
megutierrez74

Wow. All those critizing should consider their own flaws. Her decision should evoke critical though. Sad... . Sooo many sheep will do before thinking. Not her fault humans r infinitely stupid

itellitasis
itellitasis

And what exactly is "The Angelina Effect".  Smoking illegal drugs and having freaky sex from an early age? Experimenting with knife play at an early age? suffering suicidal depressions throughout teens and early twenties? She has suffered through depression, masochism, sadism and other insecurities throughout her whole life.

She had to steal a man from another woman to feel secured.  I am not sure I want my kids to know that a celebrity named Angelina even existed.

ChikuMisra
ChikuMisra

Except for the tendency to steal other women's husbands, she has got some saintly qualities, like the humanitarian thing, adopting black and brown kids, and now this. Hollywood and the media are canonizing her since they care not of adultery.

mrbofus
mrbofus

"When she named other children Vivienne or Maddox"

Do you mean when she named her other children?  Or is she going around naming other people's children?

OpenMindedSkeptic
OpenMindedSkeptic

Please educate yourself LibelFreeZone. This effects us all. Angeline Jolie is endorsing a company/monopoly that owns YOUR genes and doesn't allow other companies to study genes or administer cheaper tests. This hurts women but makes millions for Myriad Genetic Lab Inc especially after the op-ed ran in the NYTimes. The timing of this is impeccable. The Supreme Court will decide this summer if this is legal. .

so who owns your genes, Angelina?

http://timetoconsiderthelilies.com/2013/05/15/so-who-owns-your-genes-angelina/

Celebrity Breasts and Corporate Gene Patents

http://www.bcaction.org/2013/05/14/celebrity-breasts-and-corporate-gene-patents/

Did Angelina Jolie Make A Mistake By Acting On The 'Breast Cancer Gene' Theory?

http://www.greenmedinfo.com/blog/did-angelina-jolie-make-mistake-acting-breast-cancer-gene-theory

http://www.bcaction.org/2013/03/22/my-family-needs-answers/

LibelFreeZone
LibelFreeZone

Angelina Jolie "influences" me not one iota.  Sorry.

OpenMindedSkeptic
OpenMindedSkeptic

Angelina Jolie's decision to go public was irresponsible, manipulating, and disturbing. It's one thing to want to find out if you carry a mutated gene. Another to announce publicly that amputation is prevention.

RyanArbuckle
RyanArbuckle

She is going to have fun when she gets her blood pressure taken on her legs instead of the arm. Mastectomies remove the lymph nodes in the area as well. Normally, this is not a big problem as there is another arm, but with a double mastectomy, no arm is safe. The problem that happens is lymphedema, the lymphatic system is cut off by the cuff and can't return fluid back to the body, swelling the limb.

JohnSikes
JohnSikes

I bet that weirdo never had the surgery and this is a false flag to sell the gene testing

user
user

This move could have been financially motivated. A company is waiting an hearing before the court to patent the gene test for BRCA. 

If the company wins, it means the gene test will cost a lot, but a lot, more.

realsteel787
realsteel787

Breast cancer and any other cancers on Earth are easily curable and preventable 100% - no screening, surgery, chemotherapy, etc. are needed any more. Very soon they will become useless and obsolete. Every woman on Earth will never be threatened by such, or any other cancers at all, for everybody will possess the Iron Constitution...

Any pathogens can be killed once they touch you...

They say it only takes one new discovery to ensure lifetimes of generations to come...

And may I say: To the relief of everybody on Earth - that one new discovery already is a fact and any cancers and infectious diseases can be wiped out immediately, once and for all...

The way to achieve that is by doing the Immunizer - the only escape on Earth...

A recent discovery is the weapon to fight and destroy any cancers, bacteria and viruses, known or unknown on Earth. The weapon is by far more powerful than the immune system itself, keeps it intact (while vaccines devastate it) and is more powerful than anything else on Earth, it benefits everybody, regardless of age...

I call it Immunizer - just a simple exercise, but The Complete Colds/Flus/AIDS/STIs/HPVs/HBV/HCV/Chikungunya/West Nile/Yosemite/Cancers Prevention - normally done for a minute a day for kids and adults as the full prevention of any diseases - from the common cold to cancer. If done for 3 - 4 minutes a day, the immunizer will guarantee a very fast recovery for those infected by said viruses and from any forms of Cancer (Cervical, Ovarian, Anal, OSCC, Skin, Brain, Liver, Lung, Colorectal, Pancreatic, Prostate, Breast and all the rest)...

Guaranteeing everybody the Iron Constitution, the immunizer guarantees a considerable Life Extension, for it reverses aging, once your body doe not have to fight viruses, bacteria and cancers and you feel younger every day...

I will disclose my Immunizer to the whole world for 500 Billion US Dollars and all of us - kids and adults - will stay absolutely healthy, i.e. untouchable for any diseases - from the common cold to cancer all the time, all our lives. No killer viruses, bacteria and cancers on Earth got any chance against the tremendous power of the immunizer - they just die the moment they touch you...

mkb
mkb

Prevention is better than cure, what an example. indeed modern medical technology has done wonders in preventing diseases.

Human body is made of marvelous technology, Each component has evolved over millions of years of evolution experiences. we are aiming for perfection in preventing and curing diseases yet nature producing googlies or diseases. modern medical world is working hard to overcome these medical challenges overtime. 

Modern medical world has produced specialists super-specialists but We should understand the Human body as a whole.

Human body is made of Muscles and bone which forms 57% of body tissues in males and 47% in females, vital organs form 20% of body tissues rest is fat.

Modern world has produced so much of technology in every field this has made People so happy. But Human body has evolved millions of years of experience all this made Musculo skeletal tissues a redundant one. Yet every tissue is interdependent one.

Pl fallow http://mkbperfecthealth.blogspot.in/

Walking is an important activity of human life we should learn walking, foot wear is worn only by Humans.

we have Invented foot wear, foot wear that adjust to the foot in all stages of walking pl visit

http://www.ebay.com/itm/MKB-Perfect-Walking-Patent-Pending-Invented-shoes-/230979107802?pt=US_Men_s_Athletic_Footwear&hash=item35c76d7bda

mariejj
mariejj

I admire what she did. But she is privileged. The test costs $3K+. The surgery - who knows. I think the more admirable statement would have been - "I'll have this surgery when ALL WOMEN CAN AFFORD IT." How many women today suffer with breast cancer, but do not have the insurance to cover the costs. So many. She could have brought light to the fact that the US - so wealthy - so very, very wealthy - still leaves so many women with inadequate health insurance to even come close to affording her test and her surgery (factoid - in the US the test she took is patented, hence the $3K+ tab - in the UK they pay for the test...and the surgery).  I wish she would talk more to that. Make us even prouder Angelina.

LynetteCheong
LynetteCheong

@itellitasisAre you freaking kidding me? This is the most bigoted and ignorant response I've ever seen. I don't even have to be an Angelina fan to realize that your comment demonizes other people who go through the same problems. Depression, masochism, suicide, etc are all part and parcel of reality and you honestly belong to the stone age if you're gonna vilify people who go through it. If you can't recognize a person who's been through that yet still came out as successful as she did, maybe you and your kids can continue living in your little make-believe fairy tale world. Please do not breed any further.

Also, I'm quite sure Angelina was well and secure before she met Brad?

XP
XP

Nobody can be stolen and if you still think men are stolen then Aniston also stole her man from a 14 year relationship. You act like you're so pure to judge another human being. Angelina is a great role model with all her humanitarian work. God bless Angelina Jolie.

ElizabethBrasile
ElizabethBrasile

So sad that you love to put someone down for having an affair I can bet you are not pure yourself.. She is an incredible woman who does amazing things for others. Very charitable, her and Brad... Did you ever think that maybe, maybe they were meant to be? I mean Jennifer Anniston does what for others? she is very narcisstic and she too stole a man from someone, they may not have been married but they were with eachother for quite some time.. so please spare us the morality bullcrap... no one and this really includes you because your biggest flaw is your ignorance.. you need to have compassion for all, yes including Angelina Jolie... I think women are just so jealous of her.. I am a woman and I would say most women who are attractive physically go through being envied and hated. I know I was one of  them when I was younger. So coming from obviously a person who was not so blessed with looks you need to take a good  look at yourself you know get introspective... and see your faults might be considered dubious... I wish you blessings of wisdom...

IDME
IDME

@itellitasis You couldn't have said it better. Even worse is the fact that most of the news outlets forget to tell everyone that 92% of women in North America don't even have the BRCA1 gene. For God's sake.

AnjanaNetwork
AnjanaNetwork

@OpenMindedSkeptic Great insights and also, any hollywood actress can say that they had this procedure done and have the photoshopped pictures to back it up while they walk away with gobs of money. 

AnjanaNetwork
AnjanaNetwork

@OpenMindedSkeptic It appeals to her sadistic nature (she likes knives, blood, and has belonged to a sex cult since 14).  She is being canonized for being self-mutilating, now because of her influence women will feel empowered by removing their breasts.  Sad. 

KerriSandberg
KerriSandberg

@RyanArbuckle No, preventative mastectomies do not remove lymph nodes as well. Surgeons only take lymph nodes after diagnoses - yet another reason to have a mastectomy before cancer strikes if you're BRCA+.

ChikuMisra
ChikuMisra

Don't know bout fun, but will b less painful w that tight little tourniquet on leg instead of arm.

KerriSandberg
KerriSandberg

@user Actually, Myriad already has a patent on the mutation - they're trying to uphold it in court and keep the $3,000 price tag for the BRCA test. The price won't go up if the patent holds, but unfortunately it won't go down.

agroves
agroves

@mariejj Actually, I just had the screening myself recently, and my so-so health plan covered it. My genetic counselor told me that most health plans do cover the testing if there is a family history to suggest that you may have the BRCA-1 or -2 mutation. My sister died of peritoneal cancer two years ago, and that was enough for me to be able to get the test for free. Two of my close friends have also had the test free of charge due to an incidence of (nonfatal) breast cancer in the family at an early age. Usually it's a simple blood draw; in my case all I had to do was spit in a cup. The cost is going way down year by year, and the doctors and health care companies are all better educated than they used to be.

Helen
Helen

@mariejj Angeline Jolie wrote in The New York Times: "Breast cancer alone kills some 458,000 people each year, according to the World Health Organization, mainly in low- and middle-income countries. It has got to be a priority to ensure that more women can access gene testing and lifesaving preventive treatment, whatever their means and background, wherever they live. The cost of testing for BRCA1 and BRCA2, at more than $3,000 in the United States, remains an obstacle for many women."

miche44
miche44

I understand your point but I think that is an unreasonable expectation to have of her. She is human. She lost her mother to this disease and had the chance to act in a way to avoid that heartbreak for herself and her children and she acted on it. Her decision is not right for everyone. Nor, unfortunately, is is financially possible for everyone. And this is something, I feel, that needs to be addressed. But to imply that she would have been a better or moral person for NOT having the surgery is holding her to a higher (and unrealistic) standard just because she's famous. She is under no obligation to make any of us proud and I say good on her for speaking out the way she did. She has brought a lot of attention to an important issue.

Sherm
Sherm

@XP Wow, all those years I was a bachelor and I never hit on married women because I thought it was wrong.  Turns out I was wrong and it's actually okay?  Thanks XP, I'll pass this on to my kids.

LynetteCheong
LynetteCheong

@AnjanaNetwork Yes. Yes. A decision based on the medical opinions of her doctor is sure evidence of masochism. Please do further enlighten the Internet.

KerriSandberg
KerriSandberg

@thewholetruth@OpenMindedSkepticThere is no natural prevention that will trump a deleterious BRCA mutation. I was a vegetarian from the age of 13, no smoking, plenty of exercise, but I'm BRCA2+ and still developed breast cancer at age 37. I wish I'd known my BRCA status earlier so I could've had a preventative mastectomy instead of having one after diagnosis, plus chemo, radiation, a year of Herceptin, now Tamoxifen and the very real possibility that the cancer has already spread to other parts of my body and is waiting to kill me.

FoolMeOnce
FoolMeOnce

@KerriSandberg @RyanArbuckle A healthy lifestyle is the best thing you can do for prevention. Amputating yourself as a "precaution" is both disturbing and disgusting. My mothers side of the family carries the gene and my grandma and aunt both had breast cancer; but I am not going to run out and cut my breasts off. That's like losing the battle before it even begins, giving up, and also taking a huge risk. Undergoing surgery? She's probably more likely to die of complications from the surgery than cancer.

JohnSikes
JohnSikes

@AnnaMeyers @JohnSikes  

forever a skeptic am i

Excellent timing by "miss Jolie" right before the gene testing ! When certain coincidences occur one must question motives and whom has the most to gain.  I Never believe anything unless you  show me unequivocal proof  and neither should you! In this case we haven't seen this yet. Jolie has confirmed by her prior history that she is in fact a very strange individual unless you consider wearing a vile of billy bobs blood normal. Therefore one must look at whom has the most to gain as Lenin would say and that would be the Gene testing company.

realsteel787
realsteel787

@whatwouldjesusdo  

From the planet of Gods, my friend. I mean, Earth can become the planet of Gods, if everybody starts doing the Immunizer... 

KerriSandberg
KerriSandberg

@OpenMindedSkeptic @KerriSandberg @thewholetruth Yes, removing as much breast tissue as possible has been shown to radically reduce the chances of developing breast cancer. Some cells can remain after surgery, but the risk is minimal.

And FYI, the link you posted was not to a story of a woman who did what Angelina did. It was to a story about a woman who was diagnosed with cancer in one breast and chose to remove the other healthy one, and still died. That is NOT the same as having a preventative mastectomy PRIOR to a cancer diagnosis. Once a breast cancer has developed, its stems cells often circulate throughout the body and take root in the brain, lungs, liver and bones. If you can remove your breast tissue prior to the cancer growing in the first place, you are very unlikely to die of breast cancer. 

Kobe0129
Kobe0129

Clearly you aren't educating yourself. 87% v. 5% is worth the surgery. Good luck!

Kobe0129
Kobe0129

Let it go. If she wants to live her life "pretending" to be a great humanitarian them wonderful. Most of us don't even care enough to pretend. I wish someone had filmed you in your early 20s, I guess we missed your saintly youth.