The Angelina Effect: TIME’s New Cover Image Revealed

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TIME Magazine Cover, May 27, 2013
Photograph by Melodie McDaniel / Trunk Archive

Angelina Jolie has never lacked for influence. When she adopted a baby from Ethiopia, inquiries at U.S. adoption agencies about other Ethiopian orphans doubled. When she named other children Vivienne or Maddox, those names shot up the popularity charts for American newborns. So this week, when a woman known for her powerfully iconic beauty announced that she had undergone an elective double mastectomy to reduce her genetically high risk of breast cancer, it was a cultural and medical earthquake — a revelation so arresting it became the subject of TIME’s newest cover story (visit time.com/angelina to read the story; free for subscribers or purchase a digital pass.

Jolie, by nearly universal agreement, made the right choice for her. She tested positive for the breast-cancer-related BRCA1 gene, putting the probability that she would develop the disease at a terrifying 87%; after her surgery, her doctors put that number at just 5%. But a lot of experts worry that we may overread the lessons. Genetic screening is a young science, and while we may have detected genes linked to a host of ills — Alzheimer’s disease, prostate cancer, rheumatoid arthritis, diabetes, heart disease — we often do a terrible job of calculating our resulting risks. Just over one-tenth of 1% of all women carry the same BRCA mutation Jolie has, and yet doctors expect a stampede of women requesting the test. In the U.S., 36% of women who test positive opt for preventive mastectomy, but some doctors argue that regular MRIs and other screening tests may be sufficient to detect the disease, and that less radical procedures, like lumpectomies, may be sufficient to treat it if it does occur.

(Read Cover Story on The Angelina Effect, Why Her Mastectomy Raises Key Issues About Genes, Health and Risk)

Similar misunderstanding of risks is common in the case of prostate cancer too. The familiar PSA screening test detects blood antigens related to the disease, but levels of the marker can rise as a result of inflammation, infection and even riding a bicycle. Still, many men who test positive begin a cascade of subsequent tests and treatments that can often lead to a radical prostatectomy, sometimes with no real sign that they have the disease, or at least not a slow-growing case they could live with.

Human beings are very good at worrying — it’s what keeps us alive and out of harm’s way. But we’re also good at overworrying, making irreversible decisions to reduce or avoid risks that don’t really exist at all. Jolie’s brave example can make us all smarter and help keep us all healthier — but only if we take the right lessons from it.

Click here to read the full story on The Angelina Effect: Why Her Mastectomy Raises Key Issues About Genes, Health and Risk, available exclusively for TIME subscribers.
 
Not a subscriber? Click here to subscribe or purchase a digital access pass.
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torontofreedating
torontofreedating

Many women had undergone an elective  mastectomy to reduce the genetically high risk of breast cancer, especially after they tested positive for the breast-cancer-related BRCA1 gene. However, as far as i know the screening tests are not very accurate so that's a risk the patient takes. I guess a test should also be done after the tissue is removed to look for signs of cancer. http://www.torontofreedating.com/

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v.shapoval.molbio

Angelina Jolie ignores Ferromagnetic Cancer Theory (Theory from The Old Testament). According to this theory, any cancer is a subtle iron disease. Any human cell should be interpreted as a society of dia-, para-, superpara-, ferri- and ferromagnetic nanoparticles. Normal breast cells are cells with NON-NUMEROUS intracellular superparamagnetic, ferrimagnetic and ferromagnetic nanoparticles (breast cancer cells - with NUMEROUS). Breast cancer should be interpreted as intracellular superpara-ferri-ferromagnetic ‘infection’. Any intracellular superparamagnetic, ferrimagnetic or ferromagnetic nanoparticle produces an invisible area of influence around itself. When DNA or chromosomes come close to this region of space, they feel a pull or a push from the magnetic nanoparticle. Thus, DNA and chromosomes get defects and disruptions. Breast cancer is a genetic and chromosomal chaos. Cancer researchers invented a very strange BRCA1-gene/breast-cancer theory. Jolie’s mother died of breast cancer in 2007; Jolie’s aunt died of breast cancer in 2013 because Jolie’s family has an imperfect iron metabolism (the set of chemical reactions maintaining homeostasis of iron). Over 4000 human diseases are caused by single gene defects. Genetic disorders may also be complex, multifactorial, or polygenic, meaning they are likely associated with the effects of multiple genes in combination with lifestyles and environmental factors. Breast cancer can be inherited multiple-genetically and multifactorially. Iron is a well-known carcinogen. Oncologists can successfully destroy breast cancer by non-complicated anti-iron methods of The Old Testament. Anti-iron intratumoral injections [sulfur (2%) + olive oil (98%); 36.6C - 39.0C] (by CERAMIC needles) can suppress any tumors and large metastases. Anti-iron accurate slow blood loss (even 75%) [hemoglobin control], anti-iron goat’s milk diet and anti-iron drinking water containing hydrogen sulfide can neutralize any micro-metastases. Cancer researchers (who can't understand Iron Conception / Ferromagnetic Cancer Theory) can treat their daughters and mothers by 'iron surgery' (steel scalpel blades), chemotherapy, radiation and hormone blocking therapy.http://www.medicalnewstoday.com/opinions/98171/;http://healthland.time.com/2011/07/13/almost-every-type-of-cancer-kills-more-men-than-women-study-shows/;http://healthland.time.com/2013/05/15/the-angelina-effect-times-new-cover-image-revealed/;Together We (TIME, Medical News Today and Shapoval) Will Beat CANCER.

SET
SET

Jeffrey Kluger & Alice Park...

In your headline you use the term, "Preventive Mastectomy."  She had a prophylactic mastectomy.  There is a difference.  As of yet, there is no "Preventing" cancer -- there is doing everything possible to reduce risk.  Your headline is totally misleading and false and serves to add to the confusion and misinformation that surround this deadly disease.

Sherm
Sherm

Angie is the greatest human to ever live.  We should start a new religion to spread her teachings to all people:  Angieanity.

ravenaver
ravenaver

I doubt Angelina made this decision lightly. Given that her appearance is a huge part of what has made her career she has probably had to think this through in more ways than someone who is not an actress or from some other image based career would. She is clearly aware that this only reduces her risk and does not completely eliminate it. It goes from something like an 87% risk to about a 5% risk, if what I read has their facts straight. So what if she had an experimental and depressed phase to her life, many of us have. It is just that most of us don't have it publicized to the whole world. For her to come through that, especially while in the limelight, and become the woman she has become, working with the UN, creating the beautiful loving family she has with Brad, and standing strong in her decision to be as healthy for as long as she can for her family says nothing about her other than pure courage, compassion and grace. From all that I see about her, she is a woman to look up to.

megutierrez74
megutierrez74

Wow. All those critizing should consider their own flaws. Her decision should evoke critical though. Sad... . Sooo many sheep will do before thinking. Not her fault humans r infinitely stupid

itellitasis
itellitasis

And what exactly is "The Angelina Effect".  Smoking illegal drugs and having freaky sex from an early age? Experimenting with knife play at an early age? suffering suicidal depressions throughout teens and early twenties? She has suffered through depression, masochism, sadism and other insecurities throughout her whole life.

She had to steal a man from another woman to feel secured.  I am not sure I want my kids to know that a celebrity named Angelina even existed.

ChikuMisra
ChikuMisra

Except for the tendency to steal other women's husbands, she has got some saintly qualities, like the humanitarian thing, adopting black and brown kids, and now this. Hollywood and the media are canonizing her since they care not of adultery.

mrbofus
mrbofus

"When she named other children Vivienne or Maddox"

Do you mean when she named her other children?  Or is she going around naming other people's children?

OpenMindedSkeptic
OpenMindedSkeptic

Please educate yourself LibelFreeZone. This effects us all. Angeline Jolie is endorsing a company/monopoly that owns YOUR genes and doesn't allow other companies to study genes or administer cheaper tests. This hurts women but makes millions for Myriad Genetic Lab Inc especially after the op-ed ran in the NYTimes. The timing of this is impeccable. The Supreme Court will decide this summer if this is legal. .

so who owns your genes, Angelina?

http://timetoconsiderthelilies.com/2013/05/15/so-who-owns-your-genes-angelina/

Celebrity Breasts and Corporate Gene Patents

http://www.bcaction.org/2013/05/14/celebrity-breasts-and-corporate-gene-patents/

Did Angelina Jolie Make A Mistake By Acting On The 'Breast Cancer Gene' Theory?

http://www.greenmedinfo.com/blog/did-angelina-jolie-make-mistake-acting-breast-cancer-gene-theory

http://www.bcaction.org/2013/03/22/my-family-needs-answers/

LibelFreeZone
LibelFreeZone

Angelina Jolie "influences" me not one iota.  Sorry.

OpenMindedSkeptic
OpenMindedSkeptic

Angelina Jolie's decision to go public was irresponsible, manipulating, and disturbing. It's one thing to want to find out if you carry a mutated gene. Another to announce publicly that amputation is prevention.

RyanArbuckle
RyanArbuckle

She is going to have fun when she gets her blood pressure taken on her legs instead of the arm. Mastectomies remove the lymph nodes in the area as well. Normally, this is not a big problem as there is another arm, but with a double mastectomy, no arm is safe. The problem that happens is lymphedema, the lymphatic system is cut off by the cuff and can't return fluid back to the body, swelling the limb.

JohnSikes
JohnSikes

I bet that weirdo never had the surgery and this is a false flag to sell the gene testing

user
user

This move could have been financially motivated. A company is waiting an hearing before the court to patent the gene test for BRCA. 

If the company wins, it means the gene test will cost a lot, but a lot, more.

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mkb
mkb

Prevention is better than cure, what an example. indeed modern medical technology has done wonders in preventing diseases.

Human body is made of marvelous technology, Each component has evolved over millions of years of evolution experiences. we are aiming for perfection in preventing and curing diseases yet nature producing googlies or diseases. modern medical world is working hard to overcome these medical challenges overtime. 

Modern medical world has produced specialists super-specialists but We should understand the Human body as a whole.

Human body is made of Muscles and bone which forms 57% of body tissues in males and 47% in females, vital organs form 20% of body tissues rest is fat.

Modern world has produced so much of technology in every field this has made People so happy. But Human body has evolved millions of years of experience all this made Musculo skeletal tissues a redundant one. Yet every tissue is interdependent one.

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mariejj
mariejj

I admire what she did. But she is privileged. The test costs $3K+. The surgery - who knows. I think the more admirable statement would have been - "I'll have this surgery when ALL WOMEN CAN AFFORD IT." How many women today suffer with breast cancer, but do not have the insurance to cover the costs. So many. She could have brought light to the fact that the US - so wealthy - so very, very wealthy - still leaves so many women with inadequate health insurance to even come close to affording her test and her surgery (factoid - in the US the test she took is patented, hence the $3K+ tab - in the UK they pay for the test...and the surgery).  I wish she would talk more to that. Make us even prouder Angelina.

leighh
leighh

BRCA runs in my family and I have been involved in raising awareness for ovarian cancer with a project called It's time to shout for a while.

I think Doctor's can argue whatever they like.  For many women who have BRCA and that increased risk of 87%, the fear and the constant tracking can take over their lives. 

Some women i know refuse to get tested.  Some women i know have made the choice of radical surgery.  Some haven't.  But knowledge is power and having the choice through informed consultation understanding all the options, should be every person's right. 

aliberaldoseofskepticism
aliberaldoseofskepticism

I'd like to remind people, just because you're more likely to get cancer doesn't mean you will get cancer.

fabioserrano.photo
fabioserrano.photo

...Mrs Angelina Jolie...siempre ha tenido un perfil Bondadoso y de heroina...