The Dangers Lurking in Male Sexual Supplements

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“Rock Hard” and similar so-called “natural” supplements for men often contain potentially dangerous drugs — some of which have never been tested on animals, let alone humans.

In an editorial published in JAMA Internal Medicine, Pieter Cohen, assistant professor of medicine at Harvard Medical School and a colleague collected some of the lesser known facts about an industry that produces millions of pills — and likely generates tens of millions, if not billions of dollars in profits— but is almost entirely free of government oversight.

Here’s what they found:

*  A product sold as “Rock Hard for Men” in 2012 turned out to contain not only counterfeit Cialis (tadalafil)— but also a diabetes drug that can be deadly if used incorrectly.  A similar combination killed more than a dozen men in Asia in 2009.

*  One Utah company alone produced more than a million pharmaceutically-tainted pills monthly, earning $2 million between 2007 and 2010, according to an indictment issued in one of the few cases brought against such manufacturers.

*  More than three-quarters of male enhancement supplements tested in one study in Singapore contained pharmaceuticals that were not disclosed— and half of them were present in higher doses than recommended.

*  Over 45 different versions of drugs in the same class of Viagra have now been found in male sexual supplements.  A Dutch study found that 75% of the products sold in the Netherlands contained at least one analogue, or chemical variant that has the same effect as Viagra.

* A product called “Mojo Nights” recently analyzed by the Food and Drug Administration (FDA) included not just counterfeit Viagra, but also three different analogue drugs.

* Just last week, the FDA identified three tainted supplements: “Vicerex” and “Bullet Proof,” which contain counterfeit Cialis and “Lightning ROD,” which includes an analogue of Viagra.

MORE: FDA Warns Consumers to Stop Taking Sexual Enhancement Pills

“We’re talking about a massive number of brands and millions of millions of pills that are tainted,” Cohen says. “Hundreds of millions of pills are being produced every month that are spiked with these prescription medications — and worse, entirely novel drugs.” The presence of the new medications is particularly concerning since there are no data to support their safety, much less their efficacy. And they are sometimes sold alongside legitimate supplements and over-the-counter medications, so consumers often assume they are safe and tested.

The products are typically manufactured in China and sold either online or in health food or convenience stores.  The FDA and Drug Enforcement Agency (DEA) have repeatedly attempted to crack down on “legal highs” that contain analogues of chemicals such as the active ingredient in marijuana — sold as Spice or K2 — or other substances marketed as “bath salts” for recreational use. But these agencies have taken little action against male sexual enhancement manufacturers and those who illegally include active drugs in what are supposed to be “natural” herbal products.“The number of people prosecuted for this is probably less than half a dozen and the number of criminals involved is countless,” Cohen says.

“It’s so common that the FDA has been testing these pretty regularly and has set up a consumer information page,” says David Kroll, a pharmacologist at the North Carolina Museum of Natural Sciences, who was not associated with the study, but has studied pharmaceutical contamination of herbal products.

MORE: Could a New Viagra Condom Encourage Safer Sex?

Cohen urges men to simply avoid these supplements; if they contain inert ingredients, then consumers would be saving their money, but if they contain unknown drugs, they could be dangerous to people’s health. “The bottom line is that any product being sold as a natural product for male sexual enhancement should be avoided. No legal natural ingredients work and we’re seeing lots of dangerous chemicals and novel medications.”

To create these new drugs, illegal manufacturers apparently search patent applications and studies for analogue compounds that may have a similar, desired effect to the legal medication and then synthesize and sell them. Many of these agents that appear in the scientific literature may never have been studied in animal research, which makes them particularly hazardous. Some compounds may even have been abandoned for safety reasons by drug companies. And while some clearly are effective in producing arousal or sexual enhancement, their side effects are unknown.

“It’s as if they are just playing mad scientist and coming up with new chemicals and now jumping from that to popping them at pharmacological doses into these supposedly natural supplements,” Cohen says.

Such backyard drug makers might even be encouraged by the lack of enforcement of laws prohibiting improper marketing of pharmaceutical-grade agents. It’s illegal to sell prescription medications and untested compounds as herbal drugs, for example, but few are prosecuted for it. “I think it’s an enforcement issue,” he says, “The regulatory authorities are spread too thin.” He says that there are other barriers as well: those who market the products can claim that they did not know the illegal ingredients were present. “[Some] companies that import [these products] say, ‘it’s adulterated when we get it.’ I don’t know what to do about that.”

MORE: Does the ADHD Drug Shortage Herald a Crackdown on Stimulants?

To fight the illegal market, Cohen proposes making the legal drugs easier to get. “I would be for Viagra being over-the-counter,” he says, “It’s tremendously safe if you know what you’re taking,” and are given information about risks.  He recommends that for now, doctors be more generous in prescribing them, given that the risks of unknown drugs at unknown doses are far greater. If the legal drugs are simpler and less embarrassing to access, he argues, the market for the illegal versions will diminish.

Pfizer has already moved in this direction, announcing that it will sell Viagra online, with a prescription, so consumers can avoid the embarrassment of picking the drug up at a pharmacy.  The company told the New York Times the decision was part of its efforts to fight counterfeit drugs.

MORE: Erectile Dysfunction Can Be a Warning Sign for Heart Disease

As with the “legal high” market, the globalization of drug manufacturing and the anonymity and ubiquity of the internet are fueling the traffic in male enhancement pills, and generating a market for the more questionable manufacturers. But Cohen hopes the study will raise awareness of the dangers of leaving the industry with little oversight, and compel health experts and legislators to enhance their own performance when it comes to ensuring medications are safe and effective.

10 comments
ShiaLaRae
ShiaLaRae

my boyfriend has been using VigRx Plus Male Enhancement  which has been around for 13 years. Its a good safe alternative to viagra and im definitely satisfied LOL

You should check it out If you are looking for Male Enhancement products that are not cialis or viagra

mayajhonson360
mayajhonson360

These days there are flood comes of male enhancement pills.

Many of them did not complete minimum conditions requirements and they always misguided people. 

Maia Szalavitz, you told very truth about supplements, there are lot of pills which have side effects and made of chemicals.
But this is also not true that all pills or supplements are fake and made for only earnings.
There are many pills made of natural supplements and works within some days, there are not side effects after using those pills. 

You should research is there any side effects or not, is there negative effects and reviews, how many days it takes to solve erectile dysfunction, which ingredients
are used in pills, etc.  I am sharing list of pills http://www.maleenhancementdrugs.org.uk/ which got good response and reviews from users.
You can compare and used them.
 

nve360
nve360

Germany Nubian best product out there try it. It works like a charm. I know this I have tried it more then ten times it really work's. Or go get Viagra pay more and go to the docter and pay, well more!

StevanMcgrath
StevanMcgrath

I have used some male enhancement supplements to improve sex drive. I don't have to take these supplements to have sex but they do improve erection quality especially if I have been drinking. I have also taken natural text boosters, fish oils and zinc supplements and those work a little bit. I am interested in hearing about others experiences with using supplements to improve sex and sexual function. I have read some interesting reviews http://www.consumerhealthdigest.com/male-enhancement-reviews/



HenryMoontash
HenryMoontash

I'm not sure where all this misinformation is coming from.  If you want to gain penis "length" it takes time, and can only be achieved with a penis extender device!  Penis pills help to enlarge the penis by pumping more blood into the tissue of that area.  (pills by themselves will NOT increase size permanently) However, When combined, the 2 together will produce noticeable results.  Here you can see the latest reviews for 2014 for both extenders and pills - http://www.safepenisenlargement.com

Hope that helps!  

cck710
cck710

You're a man. You've got a penis and an overwhelming desire to go out and have sex with it. Why should you be ashamed of this? Nature designed us to go forth and procreate to ensure the survival of the human race. Be proud that you're a guy and you have the libido to back it up be time! - Bigger, More Intense Orgasms