First Genetic Markers That Predict Postpartum Depression

  • Share
  • Read Later

Researchers say that a blood test may soon identify which pregnant women are at highest risk of developing postpartum depression, so they can seek treatment that could control their symptoms.

Up to 20% of new mothers may experience feelings of anxiety, hopelessness, and sadness after giving birth, but doctors don’t have a reliable way of predicting which expectant moms are most vulnerable. While those with a history of mood disorders may have a slightly higher risk of feeling postpartum depression, in most cases there are few signs that foretell which women will develop the disorder in the weeks and months after they deliver.

(MORE: Pediatricians Should Start Screening for Postpartum Depression)

But in a small study of 52 pregnant women described in the journal Molecular Psychiatry, researchers at the Johns Hopkins University School of Medicine found changes in certain genes, which they could pick up in the blood, that distinguished women who went on to suffer from postpartum from those who did not. The genetic changes were epigenetic modifications, which means they were not permanent alterations in the women’s genomes but instead reflected differences in the way these genes were activated.

The scientists, led by Zachary Kaminsky, a professor of psychiatry and behavioral sciences at Hopkins, were inspired to look for the genetic changes after studies in mice. They found that estrogen, which increases during pregnancy, triggers changes in the hippocampus, a region of the brain that’s responsible for memory and mood, and that two genes were affected in particular. Not much was known about these snippets of DNA, except that they played some role in processes that are important for regulating mood — such as adapting to new environments and reorganizing neural circuits to make such accommodations possible.
It turned out the same genes were affected in women who experienced postpartum depression as well, and Kaminsky and his colleagues believe that the genes made the women more sensitive to the dramatic drop in estrogen that occured after birth. Without the estrogen, the genes may not have been as active, which could have contributed to the depressed mood that these women felt following delivery. Based on the levels of compounds made by these genes that could be picked up in the blood, these two genetic markers predicted with 85% accuracy which pregnant women went on to develop postpartum depression, and which ones did not.

(MORE: For Moms With Postpartum Depression, the Nations’ First Inpatient Unit)

To confirm the findings, Kaminsky says the test should be validated in a larger group of pregnant women who are followed for a longer period of time, but he hopes that this genetic test will identify women at highest risk — at any time during their pregnancy — and allow them to take advantage of treatments that could prevent the worst symptoms of depression. He and his colleagues have already filed a patent application for the two genes and their potential for identifying postpartum risk. “We are actively looking for partners to try to develop this finding further into a clinically useful tool,” he says. Prior research showed that recognizing and treating postpartum depression early can prevent the disorder from becoming debilitating for mothers and becoming a long term problem — for both them and their babies.
112 comments
whitehatseo1
whitehatseo1

I also benefit from learning the assessments, but learn that alot of people ought to stay on essay to try and add worth in the direction of the authentic weblog release.

aileen123
aileen123

I also benefit from learning the assessments, but learn that alot of people ought to stay on essay to try and add worth in the direction of the authentic weblog release.

SEO Consultant Scotalnd


AfiaKhan
AfiaKhan

What a really awesome post this is. Truly, one of the best posts I've ever witnessed to see in my whole life. Wow, just keep it up.somfy blinds

aileen123
aileen123

I also benefit from learning the assessments, but learn that alot of people ought to stay on essay to try and add worth in the direction of the authentic weblog release.
voli x cuba

aileen123
aileen123

Tonight only covers hotels in New York City, San Francisco, and L.A. Most people aren't stuck in those cities needing a hotel at the last minute often enough for them to go through the long process of becoming a member of this app. But I bet the app will improve its coverage with time.


monedas fifa 15

aileen123
aileen123

with Kenneth A. Lewis, a managing director at SOM, and me, technical director at SOM, acting as CASE principals. Currently more than 24 PhD, master’s, and undergraduate students actively do research and attend classes led by five professors and other guest scholars. Members of SOM’s staff collaborate with CASE investigators daily.
ACN

AfiaKhan
AfiaKhan

Once I thought about things like: why such information is for free here? Because when you write a book then at least on selling a book you get a percentage. Thank you and good luck on informing people more about it…pascal wisniec

aileen123
aileen123

I would also want to work over there in Prague so can anyone tell me how easy is it to get a job in Prague.AS I'm an Asian and fluent in English Speaking and have worked in Call Centres but obviously I have a bit of Asian tone.https://rebelmouse.com/venusfactorsystemreview/

aileen123
aileen123

I thought about things like: why such information is for free here? Because when you write a book then at least on selling a book you get a percentage. Thank you and good luck on informing people more about it!
www.rebelmouse.com/

aileen123
aileen123

The region covers more than 73,000 square kilometers. However, there are only three hospitals, 48 health centers and 358 dispensaries. Ideally, they would have one hospital per district, one health center per ward and one dispensary per village. Mens vests Sydney

aileen123
aileen123

the number of Hindu temples in Prague where tourist can see it's different culture and attractions. Temple is the center of attraction of Prague. Some of the temples are very much beautiful. I would like to visit Indian Hindu Temples in Prague. Jom Aktifkan Mykad

aileen123
aileen123

research would be the introduction of more certitude into design practice. But the greater value, and greater need, is the introduction of doubt. Currently, there may be no more efficacious way to increase both the rigor and the vigor of the profession.
Broker Vergleich

AfiaKhan
AfiaKhan

Took me time to understand all of the comments, but I seriously enjoyed the write-up. It proved being really helpful to me and Im positive to all of the commenters right here! Its constantly nice when you can not only be informed, but also entertained! I am certain you had enjoyable writing this write-up.best slim suits for men

AfiaKhan
AfiaKhan

Very informative post ! There is a lot of information here that can help any business get started with a successful social networking campaign !mobile app windows washington

AfiaKhan
AfiaKhan

I most likely appreciating each and every bit of it. It is an incredible site and decent impart. I need to much obliged. Great employment! You all do an incredible blog, and have some extraordinary substance. Keep doing awesome.mercedes benz dealer houston

AfiaKhan
AfiaKhan

I feel really happy to have seen your webpage and look forward to so many more entertaining times reading here. Thanks once more for all the details.houston used car

aileen123
aileen123

The first several months of my site there were no comments; just give it time; now they come in like crazy every day! Thanks.

klick

aileen123
aileen123

Tonight only covers hotels in New York City, San Francisco, and L.A. Most people aren't stuck in those cities needing a hotel at the last minute often enough for them to go through the long process of becoming a member of this app. But I bet the app will improve its coverage with time.

girlsdoporn

aileen123
aileen123

Thanks for writing such a good article, I stumbled onto your blog and read a few post. I like your style of writing…

bubblegum casting

aileen123
aileen123

really one of the very best in the history of articles. I am a antique ’Article’ collector and I sometimes read some new articles if I find them interesting. And I found this one pretty fascinating and it should go into my collection. Very good work!
https://www.rebelmouse.com/the3weekdiet/

aileen123
aileen123

thoroughly false division that chronically handicaps architects. An alternative, integrated paradigm conflates energy and matter, thereby drawing attention to new hybrid approaches to building materials and systems.
girlsdoporn

AfiaKhan
AfiaKhan

Pretty good post. I just stumbled upon your blog and wanted to say that I have really enjoyed reading your blog posts. Any way I’ll be subscribing to your feed and I hope you post again soon.קליפ לבת מצווה

AfiaKhan
AfiaKhan

Glad to chat your blog, I seem to be forward to more reliable articles and I think we all wish to thank so many good articles, blog to share with us.kilim Berber rugs

AfiaKhan
AfiaKhan

Truly, this article is really one of the very best in the history of articles. I am a antique ’Article’ collector and I sometimes read some new articles if I find them interesting. And I found this one pretty fascinating and it should go into my collection. Very good work!SpyBubble client login

AfiaKhan
AfiaKhan

Took me time to read all the comments, but I really enjoyed the article. It proved to be Very helpful to me and I am sure to all the commenters here! It’s always nice when you can not only be informed, but also entertained!Felipe Gibson

AfiaKhan
AfiaKhan

wow, great, I was wondering how to cure acne naturally. and found your site by google, learned a lot, now i’m a bit clear. I’ve bookmark your site and also add rss. keep us updated.Isaac Spencer

AfiaKhan
AfiaKhan

Hi! This is my first visit to your blog! We are a team of volunteers and new initiatives in the same niche. Blog gave us useful information to work. You have done an amazing job!Jennifer Webb

AfiaKhan
AfiaKhan

What a really awesome post this is. Truly, one of the best posts I've ever witnessed to see in my whole life. Wow, just keep it up.Shelby Mcdonough

AfiaKhan
AfiaKhan

Truly, this article is really one of the very best in the history of articles. I am a antique ’Article’ collector and I sometimes read some new articles if I find them interesting. And I found this one pretty fascinating and it should go into my collection. Very good work!Paulina Polk

UsamaFaisalKhatri
UsamaFaisalKhatri

Fantastic read!! I am having one of the best times of my life right now reading this. I am so grateful to you for this. Please, keep this going on! Wade Santiago

UsamaFaisalKhatri
UsamaFaisalKhatri

Wonderful work done, mate. One of the most beautiful posts that I've seen in this year. It's a real pleasure to read something as great as this. Keep it up! Louis Craig