Michael Jackson and Sleep Deprivation: Does Poor Sleep Increase Risk of Sudden Death?

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Michael Jackson allegedly relied on an anesthetic to sleep, which may have actually left him sleep deprived.

During the pop singer’s wrongful-death trial, Dr. Charles Czeisler, a Harvard Medical School sleep expert testified against concert promoter AEG Live that propofol infusions, on which Jackson allegedly relied nightly, disrupt the body’s ability to go into rapid-eye-movement (REM) sleep.

Propofol interferes with the body’s normal sleep cycle and prohibits it from getting REM sleep, CNN reports. During REM sleep, brain activity looks similar to that of people who are awake, since this is the time that memories are created and during which dreams occur. People taking propofol wake up feeling well rested but don’t actually experience the full effect of being asleep.

“It would be like eating some sort of cellulose pellets instead of dinner. Your stomach would be full and you would not be hungry, but it would be zero calories and not fulfill any of your nutrition needs,” Czeisler said during his testimony on Thursday. He said that Jackson’s alleged propofol use, administered by his physician Conrad Murray, amounted to the equivalent of being sleepless for 60 straight days.

(MORE: Why Sleep Deprivation Leads to Overeating)

Could that have contributed to Jackson’s death? It’s not entirely clear what happens biologically when the body is chronically sleep-deprived in this way — aside from feeling tired and having trouble focusing. “There is one old animal model that shows that sleep deprivation ultimately caused death in rats, but this hasn’t been replicated in other animal models at all,” says Jerome Siegel, a UCLA professor of psychiatry, director of the Center for Sleep Research and chief of neurobiology research at the Veterans Administration Greater Los Angeles Healthcare System.

Siegel says there is a misconception that less sleep can lead to a higher risk of sudden death. “Unfortunately, this drives people to take sleeping pills thinking they are preventing early death, when really, there is epidemiological evidence that chronic use of sleeping pills themselves shortens lifespan, whereas people with insomnia not taking sleeping pills have normal lifespan,” he says. “Often when people are losing sleep it means they are stressed in one way or another and high levels of stress certainly do shorten lifespan, but it doesn’t appear to be the sleep loss itself.”

(MORE: Sleeping Pills Linked With Early Death)

Relying on pills to doze off, can, in fact, be dangerous, since medications with benzodiazepines and nonbenzodiazepines, like Lunesta or Ambien, can have a wide range of effects of different body systems. “It seems nonsensical, but the benzodiazepine receptors which these pills react on are not localized to some sleep center in the brain, they are on almost every cell in the body,” says Siegel. “They are in the heart, lungs, the circulatory system; T-cells have them. The effect of taking a larger dose puts you to sleep, but in no way is it a selective activation of the sleep system, so it is not surprising there will be side effects.”

Dealing with poor sleep in other ways, including making behavioral adjustments, may be safer, he says. “It’s simply [about] keeping regular hours. You want to avoid caffeine late in the day, you want to have a regular bedtime routine, you want to minimize light and sound. It helps to keep a sleep diary to know you are doing these things,” says Siegel.

And not getting anxious over your inability to sleep can also help. He says it is important to remember that it is normal to wake up in the middle of the night on occasion, but worrying about your sleep cycles will only make dozing off more elusive.

7 comments
BrandonPenny
BrandonPenny

Its pretty shocking that NOW, all of a sudden everybody knows what happened, what caused what by what.... BUT WHY ON EARTH there was nobody to help Michael Jackson professionally, if all of the people in MJs circle (the so.called assistants, advisors, managers, lawyers...) did know about that dangerous no REM sleep...

Its really sad to know that Michael wanted the help, and was left to struggle with his fate... alone.

The question is WHY!?? At least because there were only leeches and opportunists who wanted just his money, there were so-called and self-styled friends... and nobody really wanted to help him?

Really?

We dont need to intellectually masturbate over the circumstances of his death, the propofol thing, the Murray trial... and blah blah... the thing is MJ did need the professional help and nobody really! wanted to help him, but there were so many (literally) tools how to do it.

Nobody did anything! WHY? IF... he could have got any medical (clinical, natural or alternative) help wherever in the world for any money... instead of that... the doctor pumped him up with the killing anesthesia...
oh... and now people writing comments on the net... are the judges... that MJ this and MJ that...

 Propofol is an anesthetic, not a sedative. It is used to knock a patient out for surgery, or to put into a medically-induced coma. REM sleep is not achieved by using an anesthetic.

Propofol has several side effects, one being INSOMNIA.

Michael Jackson needed to be treated for insomnia by a doctor who was experienced in sleep disorders. There are ways to treat insomnia without medications based on a patient's brain waves, bio-feedback and specialized sleep cds.

Murray did not call in help as a doctor is required to do when it is obvious that he can not help a patient.

Nothing reported during this trial is really new information.

 

Intrigued77
Intrigued77

Dr. Siegel works for the VA so I guess it is his job to insure soldiers remain alert and convince them medication is wrong for stress or insomnia when getting shot at and seeing their buddies blown up so they can remain in the field.  Does he advise the military to tell soldiers to just relax, be sure to go to bed on time even if you are in the middle of a war zone doing double duty, and to not get stressed but do some yoga when your barricade is bombed.  It does not sound like  Dr. Siegel  even believes sleep disorders exist. I wonder if he believes that PTSD  exist! I understand other meds for insomnia can have adverse side effects also but that would not have changed the pressure AEG was putting on MJ or kept the media from calling him all kinds of negative things.  And I thought Dr. Murray was Scary!  I wonder if  this is the Dr. AEG is going to use!  

ToddGilbert
ToddGilbert

He new what he was doing and was an idiot for taking it to sleep. After all it's used for an operation. That's not aeg's fault. The parents got everything out of him while he was alive now they are still trying when he's dead. He was a very troubled and pathetic creature.

BrandonPenny
BrandonPenny

@ToddGilbert AEG and its CEOs DID know about MJs problems with sleeping and the drug addictions, especially Paul Gongaware, who was with Michael on his Dangerous and HIStory tours, and he DID know about THE doctors who pumped MJ up with THE drugs instead of the professional doctors treating his addictions on some drugs..., so it wasnt anything new, especially if even people - non fans - saw that there was something wrong with MJ in the last weeks of his life... and nobody of AEG noticed? Come on..., they DID NOT want to end the rehearsals and preparations for TII tour, they DID NOT examined MJs heath, they DID NOT FORCED MJ to have any professional doctor, they DID NOT CARE about THE artist, but their money. BEFORE any signing any deal, they could have provided MJ THAT needed professional health care.

So... MJ is the one very troubled and pathetic creature?

Have you ever had any a very troubled and pathetic member of your family or a friend addicted to drugs or with insomnia?

 Since when a chronically addicted person is able to distinguish what is good for him, especially if he denies any addiction...?

Such people do need the professional help, but they cant help themselves, they think they are able to cope with that... but in MJs case, it was far worse, because he was that Michael Jackson, he had to be fit, cool, fresh, active... anytime, anywhere, however.

So you suggest that it was OK that HE wanted any strong medication or even anesthesia, and THE (any so-called) doctor was there to say YES anytime he knew its wrong, or the deadly bad decision and... then assist at giving the drugs with the doctoral degree (as a cardiologist???) knowing that MJ did not need such treatment, but proffessional help (to get rid of that insomia and no REM sleep), but.... as a doctor violated the vow repeatedly... beacuse of.. what?

I wonder, if YOU let YOUR friend or a member of you family die because of the addiction, just because you would say... - " He would not listen to them anyway! HE was his problem." and you would give your friend or family member that propofol...?

OK.... so what..., its not my prob, its his.... what a simple conclusion.
but its Michael Jackson... nah...

BTW, sleep tight and good luck... and sweet dreams.



OGingallday
OGingallday

@ToddGilbert He did anything he could to get sleep. Anyone with insomnia (including one of my parents) would and will go to great lengths to sleep. Who are you to judge someone with this condition like that? No. It's not AEG's fault. It's DNA's fault. To say he was troubled and pathetic for that. Goodbye. The irrelevance and ignorance of your comment is very clear.

ToddGilbert
ToddGilbert

@OGingallday@ToddGilbert  The ignorance of your! comment is clear. People are never responsible for themselves. DNA please ! That's ridiculous. About as dumb as the AMA declaring obesity a desease.


vgupta123
vgupta123

@OGingallday @ToddGilbert Looks like when people don't understand the real cause of any health problem, they just blame the DNA. How convenient. What the human DNA needs is a good lawyer who can sue for libel.