No More Chemo: Doctors Say It’s Not So Far-Fetched

  • Share
  • Read Later
Mark Harmel / Getty Images

There’s a revolution occurring in cancer treatment, and it could mean the end of chemotherapy.

When it comes to taming tumors, the strategy has always been fairly straightforward. Remove the offending and abnormal growth by any means, in the most effective way possible. And the standard treatments used today reflect this single-minded approach — surgery physically cuts out malignant lesions, chemotherapy agents dissolve them from within, and radiation seeks and destroys abnormally dividing cells.

There is no denying that such methods work; deaths from cancer have dropped by around 20% in the U.S. over the past two decades. But as effective as they are, these interventions can be just as brutal on the patient as they are on a tumor. So researchers were especially excited by a pair of studies published in the New England Journal of Medicine last week that showed a new type of anticancer drug, which works in an entirely different way from chemotherapy, helped leukemia patients tally up to an 83% survival rate after being treated for two years.

(MORE: On the Horizon at Last, Cancer Drugs That Harness the Body’s Own Immune System)

The report was only the latest to emerge since 2001, when imatinib, or Gleevec, the first drug to veer away from the take-all-comers approach on which cancer therapies have been built, accomplished similar improvements in survival for patients with chronic myeloid leukemia and gastrointestinal stromal tumor (GIST).

Could the end of chemotherapy be near?

“It’s a question we are all asking,” says Dr. Martin Tallman, chief of the leukemia service at Memorial Sloan-Kettering Cancer Center. “I think we are definitely moving farther and farther away from chemotherapy, and more toward molecularly targeted therapy.”

It’s the difference between carpet bombing and “smart bomb” strategies for leveling an enemy — in this case a fast-growing mass of cells that can strangle and starve surrounding normal tissues. Targeted therapies, as they are called, are aimed at specific pathways that tumor cells use to thrive, blocking them in the same way that monkeying with a car’s ignition, or its fuel intake, can keep it from running properly. The advantage of such precise strategies is that they leave healthy cells alone, which for patients means fewer side effects and complications.

(MORE: Self-Sabotage: Why Cancer Vaccines Don’t Work)

“The field is moving toward using the right drugs at the right time in the right patients,” says Dr. George Demetri, senior vice president of experimental therapeutics at the Dana-Farber Cancer Institute. “We’re moving toward a more precise understanding of cancer, and being able to tailor therapies toward an individual’s cancer.”

In the case of the NEJM studies, researchers were able to target an active receptor on immune cells responsible for enticing them to grow out of control, blocking the protein and essentially shutting down two different types of leukemia tumors.

(MORE: Young Survivors)

Already, patients diagnosed with GIST can avoid chemotherapy altogether, thanks to Gleevec. “No patient diagnosed with GIST should be getting chemotherapy today,” says Demetri. Patients who develop certain types of lung cancer or melanoma caused by a cancer-promoting mutation known as BRAF are also starting to replace toxic chemotherapy agents with new, more precise medications designed to thwart the BRAF pathway. And a study presented at the most recent meeting of the American Society of Clinical Oncology showed for the first time that a chemotherapy-free regimen led to a higher survival rate after two years than traditional chemotherapy for acute promyelocytic leukemia, a cancer of the bone marrow.

The refined approach does have a weakness, however. Cancer cells, like bacteria and viruses, are wily enough to bypass roadblocks to their survival, and often mutate to overcome the effects of targeted drugs. That’s the case for a small percentage of patients on Gleevec. But even that shortcoming isn’t insurmountable. With growing knowledge about the molecular processes that drive tumor biology, researchers are able to design medications that thwart cancer cells’ attempts to bypass medications. It’s all about staying one or two steps ahead of the cancer, and already, researchers are testing drugs that address Gleevec resistance and hoping to widen the resistance gap. “The field is moving so fast that there are new drugs already being developed to tackle new resistant clones,” says Tallman. “[Resistance] is a concern, yes, but it doesn’t negate our excitement about the future.”

(MORE: Inside America’s Drug Shortage)

Working in the doctors’ — and patients’ — favor is the fact that cancers aren’t monolithic entities composed of the same abnormal cell copied thousands of times over. Individual tumors may be composed of different types of aberrant cells, possessing a variety of mutations that are susceptible to different drugs. And this cast of cells can be ever changing over the course of an individual patient’s battle with the disease.

While such heterogeneity and unpredictability could, on one hand, make tumors too daunting to tackle, they also represent an opportunity to employ an entirely new way of fighting tumors. Traditionally, if a tumor developed resistance to a chemotherapy agent, doctors would have abandoned it completely and moved on to another drug or another treatment strategy. But now they are able to biopsy tumors and perform more sophisticated genetic and molecular tests that help them to decide, for example, that the bulk of a tumor remains susceptible to a targeted therapy while only a small portion has become resistant. They can then either remove the resistant portion surgically or add another targeted therapy to tackle just that portion while keeping the patient on the original regimen that will still treat the remainder of his cancer. “That’s a new concept,” says Demetri. “That didn’t exist before targeted therapies.”

(MORE: The Screening Dilemma — Health Special: Cancer)

For patients, these types of creative strategies could mean gentler, more tolerable cancer treatments, and more years of living cancer-free. Combinations of drugs may become the norm, much as they have become the standard for treating HIV infections. So far, says Dr. Scott Kopetz, associate professor of gastrointestinal oncology at MD Anderson Cancer Center, refined targeted-therapy cocktails appear to work best for blood-cell and immune-cell cancers like chronic leukemias that tend to be more homogenous from the start, making them susceptible to the newer drugs. Solid tumors such as those in the breast, prostate and lung generally contain a wider variety of genetically different cells even at diagnosis, which makes them more challenging — although not impossible — to treat with targeted drugs. “Where there is a lot of genetic heterogeneity, such as in most solid tumors, there is more headwind we have to fight against, more opportunities for rapid resistance to develop,” says Kopetz.

That means that for the time being, chemotherapy may remain part of the cancer doctor’s arsenal — and even these agents are being revamped to cause fewer side effects. New ways of encasing the toxin in fat-based bubbles or linking it to nanoparticles that deliver the drug just to the tumors while bouncing off healthy cells are making regimens more tolerable.

Increasingly, though, chemotherapy may become the treatment of last resort, rather than the first wave, as some basic truths about cancer are being knocked down and rewritten. For instance, it may not be as helpful to treat cancers by where they originate — in the breast or prostate or lung — but rather by the processes that fuel them. That’s why a targeted drug developed to treat melanomas is now used to suppress lung cancers, and why genetic and molecular analyses of tumors are becoming more critical to match the right medications to the right cancers.

“Many, many fundamental concepts in cancer are being challenged now based on new information,” says Tallman. “Of course that is leading to major shifts, paradigm shifts in treatment approaches and ultimately, I think, better care [for] patients and better outcomes.”

94 comments
SugarMummies
SugarMummies

Indeed i never new CANNABIS OIL could cure cancer i thought it was the end of the road for me until i met with a friend (Steve) who introduced me to these sellers of CANNABIS OIL. (cannabisoilworldwide@gmail.com)
i bought from them it was pretty expensive but had no option cause it turned out to be what i was looking for all long, a week after buying the CBS oil it was like a reborn for me.
for purchase or sales partner contact CANNABIS OIL
contact: (cannabisoilworldwide@gmail.com).

robertlowson
robertlowson


Don't be ignorant about this....

I cure all of these illnesses with my cannabis oil


CANCER

Hepatitis C

Glioma

Glaucoma

Fibromyalgia(FM or FMS)

Epilepsy

Emphysema

Diabetes mellitus

Depression

Cystic Fibrosis


*****Many MARIJUANA strains also available with us*****


CANNABIS OIL FOR THE TREATMENT OF CANCER AND OTHER DISEASES FOR SALE


Deliveries 24/7 everywhere!!!! very clean smelling, awesome taste and

VERY potent Cannabis oil. purged for hours so no impurities left

Our oils are goods for pain,cancers,insomnia and others diseases

No effects.

You can get to us by text and call us at 9515345163 or robertlowson1@gmail.com


HarvartBryant
HarvartBryant

My Husband that was highly infected with colon cancer with mets to other parts of the body, he was even given 6 months to live. God, life for the family was a living hell with sorrow in the heart, but today i shouting out to the world that the cannabis oil have save my husband from dying. he is still alive and we are in the 10 months. God is so great to the Faithful.

Thanks to Rick that sold the Hemp oil for us that we used in curing my Husband.Once again I want to thank Mr. Rick for his wnderful Hemp Oil we are now happy family with my Husband back alive, strong and healthy. You can contact Dr. Rick on every medical issue on his email:rickcancercure@gmail.com for more help.

Cindypp
Cindypp

To Rick Simpson and Phoenix Tears,


Firstly I want to thank you for the excellent cancer miracle cure guide you left in the world that cured my breast cancer. It's truly something I've never heard about before.


I've followed the exact guidelines you set out for me when i received the medication and I have now successfully free from the terrible disease  that almost take my if, your cannabis oil sensitivity drastically.


It's such a relief for me and my family and I can't wait to see what the future brings me.


Anyone out there facing this terrible disease, i would advise don't face it alone. Write Phoenix Tears At ricksimpsoncannabisoil_phoenixtears@outlook.com and get your solution.


Thank you both for this wonderful opportunity.


Cindy.

AlexBaldwin
AlexBaldwin

My name is Micheal Alex, first i like to thank God for what he done for me curing my son who have cancer of the brain for more than 10 years by sending me angel DR ELITA MARIANO who give me a medicine to cure my son cancer. at first i never believe anybody can cure cancer complete until i purchase cannabis oil from DR ELITA MARIANO it is a big surprise to me to see my son cure. for anybody who is sick of cancer or anybody who know any cancer patients to please contact Dr. Elita Mariano with this email address:: dr.emarianocancercenter@hotmail.com


Micheal


SarahWalkerPretty
SarahWalkerPretty

My battle with Breast cancer started 2 years ago, after so many Chemo, Radiation and other natural therapy treatment that i took just to cure my Breast cancer, it all did not work for my condition. I have been treating this disease for the past 2 years, but today i am here telling the world about my final victory over Breast cancer with the help of cannabis oil medication. This is a breakthrough in my family with so much Joy in our life today, i do really appreciate all the help and contribution from every member of my family for all they did for me. And if you have any kind of cancer diseases, there is no need to waste money on Chemo or Radiation, go get cannabis oil from

cancer (simpsonhempoil@gmail.com ),this is a medication that totally kill cancer cells.

KerriCollins
KerriCollins

Want to thank DR ODUMDU for helping me getting my lover back, after she has left for another woman and for what reason she did that i don't know because i always give her everything she need. after like a 3weeks she left i was not myself any more so i have to do everything in my power to have her back because the love i have for was so much that i can do anything for her. thanks to DR ODUMDU of landofsolution@outlook.com again for his help

EmilioJohnson
EmilioJohnson

My wife has been suffering from thyroid cancer which was confirmed to be stage four, the doctor told me there was little he could do since she wasn’t responding to treatment but a friend of mine came to our rescue by ordering this cannabis oil from dr godspower which he said has been helping some patient fight against cancer of various types so we decided to give it a chance, so far my wife is improving perfectly very well and presently she can walk around the house all by herself. I felt its necessary i let others who are suffering from this acute disease that once you have a good cannabis oil from dr godspower, it can really give one a sound second chance of living. by chance if you happen to be in need of this cannabis oil you have to contact dr godspower who supplied I and my wife with his email: ozalogboshrine@gmail.com

Annie008
Annie008

I want to thank Rick Simpson and the entire management of Ricksimpsoncurefoundation and their life saving cannabis oil that cured my breast cancer, so many doctors told me that there was no hope for me since i was not responding to treatment despite all the chemo and radiation. So a friend of mine came to my rescue by making me ordering this cannabis oil from Rick Simpson cure foundation which she said Rick has been helping patients to fight against cancer of various types so i decided to give it a try, and i ordered for the good cannabis oil for that of 60 grams which cost me $1500 usd. So far i have really improved and now i am very okay like never before. I felt it's necessary i let others know this good news especially those suffering from this ugly disease that once you have a good cannabis oil, from Rick Simpson Cure Foundation, it can really give a second chance in life. If it happen that you are among those suffering and dying of this disease and you really need this cannabis oil, you can contact the foundation and you can order and purchase this good cannabis oil from the foundation on their email on

Ricksimpsoncurefoundation@yahoo.com

SalmanMehmood
SalmanMehmood

Dishidrotic eczema primarily affects the hands and feet, although can affect the face as well and looks like blisters. This particular form of eczema has the potential to be very uncomfortable as the sores tend to run quite deep beneath the skin. http://pinewardrobesantique.weebly.com/

SalmanMehmood
SalmanMehmood

Eczema is a skin condition which manifests itself in skin irritation and continual itchiness. The key thing to think about here is that it can be very easy to just dismiss the above symptoms as a one time occurrence, similar to walking through a patch of poison ivy and having to deal with the continual itchiness, appearance and urge to scratch. http://watchrepairforum.blog.com/

SalmanMehmood
SalmanMehmood

But what is it, and have you ever believed "what does acne look like?" After all, if you think you may have it, you should know how to creatively identify it as this is the first thing to dealing with this situation. http://www.edwinochoa.com

AloneSchaub
AloneSchaub

Unless you 're a product new start-up in a area you know nothing about, possibilities are outstanding that you know your organization far better than your SEO consultant, so consultant knowledge should be a part of your strategy. http://upliftinggreatquotes.tumblr.com/

SalmanMehmood
SalmanMehmood

For those that have issues with gluten based foods, there is the usual digestive problems but this can also lead to ulcers as well as eczema.  http://physiciandepot.com

FaizaKhan
FaizaKhan

It is a design of songs that became popular in the early 1900's, and different tastes of boogie-woogie songs are observed in many songs designs nowadays. One of those designs now happens to be childrens' songs. http://animeop.tv/naruto-movie-4-the-last/

SandraBrandon
SandraBrandon

I want  to quickly tell the world that there is a real on line that cure cancer with cannabis oil,


my name is Sandra Brandon from United State am suffer from diagnosed of breast cancer  3years ago and i have done chemo surgery and i was not cured from this deadly disease  is basically a Death Sentence on my life, the thoughts of having Breast Cancer burns and itches simultaneously in my heart that i was dead alive (and looks hideous). I heard that Hemp Oil could help, and for the price i was willing to try anything that would save my My Life. What I found out was astonishing! It was instantly getting better and better and most of the virus are gone and just little medication left for me. It’s also a light, i am very grateful to Dr. UZOYA for Selling the cannabis Oil that cured my breast cancer, for me and his Medical Advises,Those facing health challenges should go for cannabis oil to ensure the absolute cure of all kinds of cancerous diseases.contact him Email Address;druzoyasolutioncentre@yahoo.com




 IF YOU HAVE ANY PROBLEM CANCER DISEASE NAMED BELOW:

1.ASEPSIS

2.      GONORRHEA

3.MENOPAUSE DISEASE

4.LOW SPERM CAN

5.      HIV/AIDS

6.EPILEPSY

7.LASSAS FEVER

8.CANCER

9.      BREAST CANCER

10.    OVARIAN CANCER


if you need help contact his Email Address:druzoyasolutioncentre@yahoo.com..

sajj1970
sajj1970

Thanks Sandra for sharing a very useful info and his email ID. I'll definitely get in touch with him. Actually my wife is suffered from carcinoma breast cancer at grade 3 and she went through lumpectomy surgery last month. Now she is preparing herself for chemotherapy sessions as advice by the doctor which are going to be scheduled in due course of time. Kindly keep me posted about your well being at the following email and/or my cell no: sajjadsiddiq@yahoo.com,

00923455091150

May you get well soon completely.

With regards, Sajjad

SandraBrandon
SandraBrandon

I want  to quickly tell the world that there is a real on line that cure cancer with cannabis oil,


my name is Sandra Brandon from United State am suffer from diagnosed of breast cancer  3years ago and i have done chemo surgery and i was not cured from this deadly disease  is basically a Death Sentence on my life, the thoughts of having Breast Cancer burns and itches simultaneously in my heart that i was dead alive (and looks hideous). I heard that Hemp Oil could help, and for the price i was willing to try anything that would save my My Life. What I found out was astonishing! It was instantly getting better and better and most of the virus are gone and just little medication left for me. It’s also a light, i am very grateful to Dr. UZOYA for Selling the cannabis Oil that cured my breast cancer, for me and his Medical Advises,Those facing health challenges should go for cannabis oil to ensure the absolute cure of all kinds of cancerous diseases.contact him Email Address;druzoyasolutioncentre@yahoo.com




 IF YOU HAVE ANY PROBLEM CANCER DISEASE NAMED BELOW:

1.ASEPSIS

2.      GONORRHEA

3.MENOPAUSE DISEASE

4.LOW SPERM CAN

5.      HIV/AIDS

6.EPILEPSY

7.LASSAS FEVER

8.CANCER

9.      BREAST CANCER

10.    OVARIAN CANCER


if you need help contact his Email Address:druzoyasolutioncentre@yahoo.com

FaizaKhan
FaizaKhan

 In internet market strategies, it is most important technique so the exposure of your web page is improved and it efficiently gets to the target viewers.  http://tiny.cc/8fv6px

MarisaMartin
MarisaMartin

My wife has been suffering from thyroid cancer which was confirmed to be stage four, the doctor told me there was little he could do since she wasn’t responding to treatment but a friend of mine came to our rescue by ordering this cannabis oil from ozalogbo which he said has been helping some patient fight against cancer of various types so we decided to give it a chance, so far my wife is improving perfectly very well and presently she can walk around the house all by herself. I felt its necessary i let others who are suffering from this acute disease that once you have a good cannabis oil it can really give one a sound second chance of living. by chance if you happen to be in need of this cannabis oil you can contact ozalogbo who supplied I and my wife with this email: ozalogboshrine@gmail.com

FaizaKhan
FaizaKhan

What should the supplier be looking for? This content will talk about the kind of solutions provided by both categories and help the organization supplier choose which expert to use. http://seoservicetp.mono.net/

FaizaKhan
FaizaKhan

He had assured Doc Deneeka that anyone who continuous to offer to fly tasks over opponent area after attaining the compulsory 45 objective focus on was not only insane, but was so disrupted he should be sent house for his own protection. 

http://physiotherapyprogram.wordpress.com/

dr.douglasmackenzie
dr.douglasmackenzie

If doctors are claiming that it is not so far-fetched to imagine a time without chemo then it is one of the most delighting news. This will revolutionize the treatment of cancer. Reviews on oncologists are helping spread news on research and development in the field of oncology.

ChloeDwayne
ChloeDwayne


I and my boyfriend were meant to be forever but he met another girl at his work place. She did everything to break us apart B'cos she was younger and attractive, and finally my boyfriend moved in with her. I tried few cheap spells but to no avail then I ordered the most powerful love spell from robinsonbuckler @ yahoo. com and I don't regret it!  i and my boyfriend are back together and happier than ever. if you are heart broken and you want your lover back contact this spell caster Robinson, he is A top spell caster of the season, he has such a perfect view on love spells that I believe he can solve any case given to him. I recommend his love spell to couples in need of help. Use his services
Chloe DWAYNE

brix
brix

If diagnosed with cancer illness, treatments involves radiation and intravenous drips of cytotoxic chemicals are used in combination to make up what is known as chemotherapy. The side effects, both short term and long term, can be harsh.


http://matterprints.com Matter Prints




sugar888
sugar888

There are already non-chemotherapy treatments which does not affect the good cancer cells. With this alternative treatments may soon be a recommended curing option.


http://skogvard.com skogvard.com

Lit
Lit

There are many different chemotherapy drugs with the potential for many different side effects. These effects vary from person to person and from treatment to treatment. 


<a href="http://ihubsolutions.com.hk>Hong Kong Storage</a>

AmyMorgan
AmyMorgan

My journey with cancer began when my dad died from cancer soon after I turned 5 years old. He was a physician and a wonderful man. He saved other people’s lives. He saved my best friend when she had spinal meningitis at the age of 4.

We’ve been best friends ever since.
Right before I found out I had breast cancer, I had just completed my Master of Education degree in Creative Arts at Carthage College in Kenosha, Wisconsin. It was May 2007. My life during that time was so busy. I was a single mom, teaching full time, and going to Carthage two nights a week. The news of cancer made my life come to an abrupt halt.
I was diagnosed with stage II invasive ductal carcinoma breast cancer on August 11, 2007. I was alone, sitting in my living room with the phone, waiting. The doctor called around 9:15 a.m. I was devastated with the news. I remember feeling numb and wanting to deny the truth. I started to think of all of the reasons why I probably got cancer—blaming myself. I sobbed and prayed at the same time. I pleaded with God to not let me abandon my children from cancer like my daddy, who I still missed dearly.
Then I decided to use my energy in a positive way and learn about breast cancer. I went online. That’s when I saw how cannabis oil has saves life, so i order the oil and started using it and my breast cancer is gone. you can contact them via: ricksimpsoncancerfoundation@gmail.com.

yasirkhalid1993
yasirkhalid1993

Lots of clinical trials by Top health professionals suggest that Garcinia HCA is a most strong fat burner, not only that it also seen on most popular TV shows. Dr. Mehmet Cengiz Oz coined Garcinia Cambogia as the “Holy Grail of Weight Loss.” http://garciniacambogiaofficial.com.au/

FaizaKhan
FaizaKhan

Blog Leaving reviews and Look for Motor Marketing. As mentioned before, blog commenting can actually have a benefits with regards to search engine optimization for a couple of reasons. http://discountkeylessremote.com/

ClaireM
ClaireM

Well, rumor has it that the corporate medical world is suppressing any alternative cure for cancer except of course if they are already providing it like chemo machines and medicines. 


http://matterprints.com

YG
YG

Traditional chemotherapies work by killing cells that divide rapidly. But as they wipe out fast-growing cancer cells, they also can damage fast-growing healthy cells.

http://www.seosubmit.com

SugarMummies
SugarMummies

@YG Indeed i never new CANNABIS OIL could cure cancer i thought it was the end of the road for me until i met with a friend (Steve) who introduced me to these sellers of CANNABIS OIL. (cannabisoilworldwide@gmail.com)
i bought from them it was pretty expensive but had no option cause it turned out to be what i was looking for all long, a week after buying the CBS oil it was like a reborn for me.
for purchase or sales partner contact CANNABIS OIL
contact: (cannabisoilworldwide@gmail.com).