Acetaminophen Linked to Fatal Skin Reactions

  • Share
  • Read Later
stockcam / Getty Images

Acetaminophen is one of the most widely used medicines for fever and pain, commonly found in drugs like in Tylenol. On Thursday, the Food and Drug Administration (FDA) announced that acetaminophen is causing rare, but dangerous skin reactions in some people.

The popular pain-killing medication is linked to three skin diseases with symptoms that range from rash and blisters to more extensive damage to tissues under the skin. The two most serious skin conditions are Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN), which will typically require hospitalization and can be fatal. The less dangerous skin disease is acute generalized exanthematous pustulosis (AGEP), which usually resolves itself within two weeks once acetaminophen is stopped.

Many of the reactions start with flu-like symptoms of fever and muscle aches, which are followed by rash, blistering and sloughing off of the outside of the skin, which can expose patients to potentially fatal infections. It’s possible for victims to experience scarring, skin pigment changes, blindness and organ damage. The recovery can take weeks or months. The FDA says anyone who is taking acetaminophen and is experiencing skin symptoms, should stop taking it immediately.

(MORE: Doctors Not Informed of Drug Side Effects During Sales Visits)

“This new information is not intended to worry consumers or health care professionals, nor is it meant to encourage them to choose other medications. However, it is extremely important that people recognize and react quickly to the initial symptoms of these rare but serious, side effects, which are potentially fatal,” said Dr. Sharon Hertz, the deputy director of FDA’s Division of Anesthesia, Analgesia and Addiction in a statement.

The FDA says it will require manufacturers to add warning labels to all prescription medications that contain acetaminophen and will work with makers of the over-the-counter drugs to do the same. The FDA discovered the risk of skin diseases while reviewing adverse events reported in its database between 1969 and 2012, during which 107 cases of significant skin reactions were reported, 67 people were hospitalized and 12 people died.

It’s not clear why the skin conditions have not emerged as a health concern sooner, given how many people take the pain-killing medication. Health officials say it’s too soon to determine whether does is an issue, or whether the combination of acetaminophen with other ingredients or medications causes the adverse events. Often, such side effects only become apparent once a drug reaches market and is used by millions of patients, since manufacturers cannot anticipate every potential interaction between their product and others. For example, some statins, which lower cholesterol and reduce inflammation, were discovered to raise the risk of diabetes and other painkillers known as Cox-2 inhibitors were linked to an increased risk of heart attack and stroke.

(MORE: How Our Web Searches Could Expose Drug Side Effects)

The announcement isn’t the first to alert users to the potential harms of acetaminophen. Two years ago, the FDA limited prescription acetaminophen doses to 325 milligrams per tablet or capsule to prevent liver injury. For now, the FDA says people using the drug should not stop the medication unless they develop skin symptoms. The side effects are rare, and for most users, the agency says the benefits of the drug outweigh its risks.

452 comments
AmyRossland
AmyRossland

Can I simply say what a relief to find a person that really understands what they are discussing on the net. You definitely understand how to bring an issue to light and make it important. A lot more people ought to look at this and understand this side of the story. I was surprised you aren't more popular given that you definitely possess the gift.

Super Visa Canada

BradSoverty
BradSoverty

Having read this I thought it was extremely enlightening. I appreciate you taking the time and energy to put this short article together. I once again find myself personally spending a lot of time both reading and posting comments. But so what, it was still worth it!

Edmonton Mortgage Broker

rnkiss
rnkiss

Yes good old FDA always watching out for us, they approved the GMO's they force on us. Why am I not surprised? Glad I never used Tylenol, it never did anything for me when I did try it.

nomi
nomi

web design colchester

Obtaining good football instructors and also tennis mentors is challenging. The the greater part are past college or high school graduation players which look moderately good reaching a basketball, but have got little genuine teaching knowledge..

nomi
nomi

Onpage Seo Service

 our blogs further more each else volume is so entertaining further serviceable It appoints me befall retreat encore. I will instantly grab your rss feed to stay informed of any updates...

nomi
nomi

I thought it was going to be some boring old post, but it really compensated for my time. I will post a link to this page on my blog. I am sure my visitors will find that very useful msexcel

AfiaKhan
AfiaKhan

Bike Race 3D" for FREE on android Google play now! Are you ready for Bike Race? Start your engine and gear up to race down the track. An Amazing racing game features with exciting race tracks to compete with your extreme rivals. Be an extreme moto racer and drive the world class sports bike. Win race to Unlock & upgrade new bikes to challenge your opponents.Moto Racing

aileen123
aileen123

If it were true that 4.9m people, or more than 21 per cent of the workforce, were jobless, Spain would not be as peaceful as, barring a few demonstrations, it has so far been, say economists and business leaders.
SEO Consultant Glasgow

AfiaKhan
AfiaKhan

It is really no surprise that this building was found to have bed bugs infesting it. I mean, it is in New York city, which is pretty disgusting itself. And some of the people who work there, even if they do make decent wages, probably don't make enough to afford what is considered a "nice" place to live in New York City. Especially in midtown, of all places.FLING #1 DATING SITE IS HERE JOIN NOW FIND SOMEONE NOW STOP BEING ALONE !

AfiaKhan
AfiaKhan

I found Hubwit as a transparent s ite, a social hub which is a conglomerate of Buyers and Sellers who are ready to offer online digital consultancy at decent cost.MADF

aileen123
aileen123

If it were true that 4.9m people, or more than 21 per cent of the workforce, were jobless, Spain would not be as peaceful as, barring a few demonstrations, it has so far been, say economists and business leaders.
bikini sauvage

AfiaKhan
AfiaKhan

I'm impressed, I must say. Very rarely do I come across a blog that's both informative and entertaining, and let me tell you, you've hit the nail on the head. Your blog is important..online business opportunity

AfiaKhan
AfiaKhan

I’m excited to uncover this page. I need to to thank you for ones time for this particularly fantastic read!! I definitely really liked every part of it and i also have you saved to fav to look at new information in your site.somfy blinds

AfiaKhan
AfiaKhan

Apotex is populated by a multicultural network of people, lending a wide range of experience and offering boundless opportunities. Through the company's social committee, employee events serve to cement a team-centric attitude pervasive in every aspect of life at the firm.here

AfiaKhan
AfiaKhan

Dr. Paul Lubitz is a licensed Canadian dermatologist with over ten years of experience in the field. Currently practicing at his Bow Valley Dermatology clinic, located in Canmore, Alberta Click here

AfiaKhan
AfiaKhan

Dr. Paul Lubitz is a licensed Canadian dermatologist with over ten years of experience in the field. Currently practicing at his Bow Valley Dermatology clinic, located in Canmore, Alberta Click here

AfiaKhan
AfiaKhan

Larry Weltman works as a Customer Service Rep. at AccessEasyFunds Ltd., the country’s leading commission advance company that helps real estate professionals fund their commissions.here

AfiaKhan
AfiaKhan

Thank you for your post, I look for such article along time, today i find it finally. this post give me lots of advise it is very useful for me.London sash window company

DorelTanase
DorelTanase

I buy Acetaminophen, from Holand last week. I com whit details soon about this product.

AfiaKhan
AfiaKhan

Det beror på vilken vätska mobiltelefonen är tappat den i, olika vätskor orsakar olika mycket skador. T.ex. tappar du mobilen i havet/saltvatten så lär mobilen rosta inneifrån väldigt fort vilket kan medföra stora rostskador på din iphone om inte man snabbt gör något åt saken och öppnar den för att kunna torska bort all vatten. Laga iPhone i Kista Galleria Stockholm. Snabba iPhone reparationer billigt. Tappar man den i vatten så är det jätte bra att låta mobilen ligga i ris i minst 24 timmar men man bör även gå in snabbt till en iphone reparatör och undersöka saken så fort som möjligt för att kunna fastställa om det går att rädda sin kära iphone eller inte. Det man räddar först och främst i iphonen när det gäller hårdvara är i förstahand moderkortet då den är som telefonens hjärta och hjärna.reparation iPhone 6 glas