Scientists Hail Major Breakthrough in Treating Alzheimer’s in Mice

A new drug compound has successfully prevented degenerative diseases from destroying brain cells in mice.

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According to a study published in Science Translational Medicine this week, British researchers say they have achieved a breakthrough that could led to a revolution in the treatment of Alzheimer’s disease.

The researchers say that a drug they developed stopped degenerative brain diseases in lab mice. The drug prevents neurons from being destroyed by targeting how the brain reacts to abnormally shaped proteins responsible for neural degeneration.

(MORE: Promising New Tactic Found in Battle Against Alzheimer’s Disease)

“We were extremely excited when we saw the treatment stop the disease in its tracks and protect brain cells, restoring some normal behaviors and preventing memory loss in the mice, ” scientist Giovanna Mallucci told Sky News.

[Sky]

56 comments
neurons100
neurons100

TAP-A-CISE, The Tapping Solution To Preventing Alzheimer's Disease (Epigenetics) [Kindle Edition] amazon.com
Retha Horne (Author), CYTOLOGIST
Be the first to review this item
Digital List Price: $0.99
Kindle Price: $0.99

THIS BOOK TEACHES YOU HOW SIMPLY TAPPING YOUR FOREHEAD GENTLY CAN BRING UP SHORT TERM MEMORY RECALL.. YOU MUST EDUCATE YOURSELF TO TAKE THE FEAR OUT OF ALZHEIMER'S DISEASE. THE BOOKS GOES INTO DETAIL ON HOW EXERCISE INCREASES THE CAPILLARY EXCHANGE PROCESS TO REGENERATE NEW HEALTHY NEURONS OR BRAIN CELLS 

oldandproud
oldandproud

I am 77 years old and I have seen dementia reversed in Europe but the Big drugmakers get in the way looking for profit.  

All the funding go to Big Pharma and none to natural research that has been proven in labs.  Natural research sits on a shelve because the drug makers cannot profit from natiural, they need a drug.

 Researchers in Europe and S.America showed that a special combination of natural ingredients was reversing dementia and Alzheimer's in even late stages. It worked..but when the drug makers found out that all the ingredients were natural and they could not profit off the diet they dropped the researchers. The diet was still online in many countries, it worked

Here http://malalzheimer.blogspot.com/2013/03/how-to-reverse-alzheimers-disease-what.html


cetude
cetude

Alzheimer's disease is more complex than this.  Most people I seen with it became inactive and just sit around, and live to eat and watch TV.  Their brains DEGENERATE and the progression is steady due to lack of necessary stimulation.  It's like a muscle that isn't used.  There is no magic pill for this.  These claims are preposterous  they just are trying to get more government funding wasting our tax payers' dollars.     The people who don't get this disease have interests - their mentality stays intact - because they use their brains. 

cetude
cetude

Scam.  Governments are trying to cut funding so these "breakthroughs" come out to "justify" getting more government money - I heard these garbage claims over and over again.  Just like they say they can cure AIDS.  Yeah, right.  "Functionally cured" means they are stil infected - but young people will believe HIV can be 100% cured so they have group sex and do whatever and spread their HIV around.  Since they published - erroneously - they can be "cured". 

DonnIrving
DonnIrving

Science is successful in many areas today because the field has been able to move beyond "Dark Age" thinking. now the science efforts are noted for persistence and patience. 

ZeForte
ZeForte

this is excellent news... for democRats with alzheimers... after all, their brains are essentially the same as those in mice or rats.

DannyBravo
DannyBravo

alzheimere  is  the  same  causes  of  diabetes,,  defective  blood  is  the  causes  of  2  desiase  not  the drain,,  or  not  the  heart  if  the  blood  are  loosen  the  1  element  of  blood  like  the  plasma  all  the  organ  will  damege,,,,,  this  is  like  the  winner  of  award  for  transforting  cells  and  the  carbon  dioxide  for  climate  change,,,  contrary  for  the  real  treatment,,,  for  create  a  money,,  long  term  of  job  for  the resarcher,,  and  favor  of  taxes  to  the  govt  for  the  oil...  stop  lying  the  people

tymmac007
tymmac007

That's awesome, I can't wait to what were we talking about again?

scienceinlaw
scienceinlaw

"The researchers say that a drug they developed stopped degenerative brain diseases in lab mice."

No, they don't say that.  "Diseases" the last time I checked, is plural - and only 1 model for 1 disease was actually tested in this study.  In fact, if you go to Science Translational Medicine and look for "Alzherimer's" - you won't find this article show up.  What the authors actually say that in the mouse model of PRION disease on which they tested the drug (PERK inhibitor), that the drug suppressed a coping mechanism that's actually deleterious in this model of the disease... again, in that particular genetic model.  They say it could have utility outside of this genetic model, but that's purely speculative (not an unreasonable hypothesis, but this is classically bad science journalism in action -- this is not the major point the authors are making!).

JeriSteckling
JeriSteckling

My father has Alzheimers and I am his caretaker.  People who comment here should know how much we pray that there will be a treatment/cure for this terrible disease. It is not a story to make fun of. We all could be in my Dad's or my shoes someday. 

dfiantwolfe
dfiantwolfe

Who wants to guess that the main ingredient is either THC, or THC that's been altered some how.

franciskelly6
franciskelly6

At long last, now I can prevent my pet mice from getting lost while driving!

Sardis
Sardis

I remember they had this breakthrough 5 years ago... they just forgot it happened...

rpearlston
rpearlston

@cetude Has it ever occurred to you that you have backwards?  Recent studies have indicated that by the time Alzheimer's is diagnosed, the patient has had it for over a decade, and that prodromal (the very first) symptoms are exhibited years before that.  THAT's why people become less and less active as the disease progresses.

This story isn't about nothing.  It's not planted to distract anyone from anything here, including from the truth.  Your failure to understanding the relationship between the progression of Alzheimer's and physical inactivity is the problem here.

My family is LIVING with this, and with a lot of the complexities and complications that it entails.  You, apparently, have had only occasional glimpses into the world of Alzheimer's, and have made a horrible misstatement because of it.

rpearlston
rpearlston

@skrome Of course not.  Yet.  And yet is the operative word.  Animal studies of potential human meds means that such  meds are in the very beginning of clinical trials.  There are still a number of steps that need to be taken, and only after the governing body (in the particular country) is satisfied with any given n stage can the trials move on to the next stage.  This is the first stage, and if it's successful, it will be some years yet before doctors will be able to prescribe it.

The understanding that the development of any new med can take years (and why) is crucial to understanding of the significance of such studies.

rpearlston
rpearlston

@DannyBravo How about if you stop lying to people.

Blood has nothing to do with this.  Diabetes is an autoimmune disorder (genes, not blood).  And Alzheimer's looks much like the effects of CTE (chronic traumatic encephalopathy).  There's a possibility that they, too, are about autoimmune disorders. Again, autoimmune is NOT about blood, but about genes.

You are woefully ignorant in this matter.  I hope that it's an accident, and not a deliberate lack of knowldge.  Either way, educating yourself, even a bit, will make a huge difference.

rpearlston
rpearlston

@RobertBain That's a different disease entirely, with a disease process very, very different.  After all, Parkinson's gradually destroys the ability of the body to respond as you wish while you keep your cognitive abilities , and Alzheimer's allows the body to live reasonably unchanged (except for aging) but destroys the minds of it's victims.

There's ongoing research on both, and many other problems, too.  BUt today is the day for Alzheimer's researchers to have the spotlight.

ChrisLaw
ChrisLaw

Give me just 5 minutes with your sarcastic arse and I`ll leave you with marks you`ll ALWAYS remember!!! :)



rpearlston
rpearlston

@beatstockpromotersdotcom If you had any clue about the regulatory process involved here, the process that rules the rate of clinical tests of and decisions to allow the sales of, any new med, you wouldn't be talking about 40 years.  

neurons100
neurons100

@JeriSteckling  Be sure to educate yourself on the cellular mechanism of Alzheimer's and its reversal process so you won't be completely dependent on medication.  Exercise and proper diet with a multivitamin with mineral and plenty of water will maintain sufficient neurogenesis to combat the progression of Alzheimer's.

DonnIrving
DonnIrving

Go9d bless you for your caring of your father. You're absolutely right, it is not something to poke fun about.

bryan.dhn
bryan.dhn

@JeriSteckling I agree with you. And I lost my mom about 20 days ago to this terrible disease... how sad the way people treat others, with no respect at all to our feelings... 

ggonz24
ggonz24

@JeriSteckling Mother Passed away at the early age of 65 by this terrible disease. None of the drugs out there are doing anything this is huge if it can do the same to humans

arose4yu
arose4yu

@JeriSteckling I lost my Mother to Alzheimer's and my sister's mother-in-law is currently dealing with it...it is a horrible disease and I am so happy that they have made strides...this is great news.

janamarie38
janamarie38

could the world possibly get any more ignorant?

this is cruel and not amusing or humorous on any level

arose4yu
arose4yu

@franciskelly6 not funny. You need to educate yourself...it literally shuts down your body from functioning..not just memory loss.....you can get the disease as early as 30. You do not want to ever get this or have someone in your life that has it...so making asinine jokes like this really says alot about your ignorance.

cps
cps

@Sardis Remember when that joke was funny? Neither do I.

neurons100
neurons100

@rpearlston @RobertBain TAP-A-CISE, The Tapping Solution To Preventing Alzheimer's Disease (Epigenetics) [Kindle Edition] amazon.com
Retha Horne (Author), CYTOLOGIST
Be the first to review this item
Digital List Price: $0.99
Kindle Price: $0.99

THIS BOOK TEACHES YOU HOW SIMPLY TAPPING YOUR FOREHEAD GENTLY CAN BRING UP SHORT TERM MEMORY RECALL.. YOU MUST EDUCATE YOURSELF TO TAKE THE FEAR OUT OF ALZHEIMER'S DISEASE. THE BOOKS GOES INTO DETAIL ON HOW EXERCISE INCREASES THE CAPILLARY EXCHANGE PROCESS TO REGENERATE NEW HEALTHY NEURONS OR BRAIN CELLS

MargieMcCormick
MargieMcCormick

@bryan.dhn @JeriSteckling I'm sorry for your loss. My Mom has something similar, and every day is a challenge for me, and scary for her. She knows she has a problem, which is probably the worst part. It's no way to live, and she frequently says she wishes she could just die. I want her to live on because I think maybe something miraculous could happen & she could get better.

rpearlston
rpearlston

@ggonz24 @JeriSteckling Actually, there are drugs that can help to slow the progress of Alzheimer's, depending on the stage you're in.

Jeri, I'm in your shoes, too.

AngelOG
AngelOG

In his defence, he may be correct. THC and the many other cannabinoids in the cannabis plant have a profound effect on glutamate regulation at or near the synapse in a neuron; which is a significant factor in the disease process of Alzheimer's and dementia and many other degenerative diseases of the nervous system. Google glutamate and cannabinoids and you'll have all the proof you need. Cannabis resin is loaded with proven neuro-protecting compounds. I for one think defiantwolfe's comment is a serious one and should not be overlooked.

rpearlston
rpearlston

@arose4yu @franciskelly6 At 30?  Try at half that age kids who have been playing contact sports can be showing clinical signs of cognitive problems.  IF they happen to die, for whatever reason, and their parent's give permission for an autopsy. their brains will show distinct changes that indicate CTE, a condition that mimics that of Alzheimer's.

bryan.dhn
bryan.dhn

@arose4yu @franciskelly6 lost my beloved mom 20 days ago to Alzheimer. She was a sweet woman and it was REALLY sad to see how she ended her days... I wouldn´t wish this disease to anyone... Please, be careful when making comments cause you´re touching someone else´s emotions and feelings. 


neurons100
neurons100

@rpearlston @MargieMcCormick @bryan.dhn @JeriSteckling  I am a cytologist.  I wrote the original hypothesis over a decade ago explaining the mechanism of how exercise increases the blood flood of oxygen and nutrients to the stem cell layer of the brain to nourish and maintain neurogenesis.

I did this as a humanitarian effort, because,  there was a severe need to dispel the dogma that neurons do not regenerate.  Since then there have been over 800 studies funded by National Institute of Health to validated  by PET scans before and after exercise that neurons do indeed regenerate.

People have to take control, through educating  themselves  Each person is different.  There are different clinical causes that diminish neurogenesis and you have to personalize your regimentation to prevent or reverse this cellular degenerative process. 



rpearlston
rpearlston

@MargieMcCormick @bryan.dhn @JeriSteckling YOu and your mother need to see a good gerontologist, if you're not already doing so.  There are things that she can do now, and you'll come away with a realistic view of the possibilities for your mother.  She may be speaking as much out of boredom than anything else, and there are likely programs near her than can keep her as active as possible, physically and cognitively.  My mother is in one such program, but you and I are probably in different countries, so telling you where my mother is going is moot.  I hope it's enough for both of you to know that there is help available.

Alexander_S_
Alexander_S_

@AngelOG @beatstockpromotersdotcom @dfiantwolfe  The Federal Government has a patent on the use of CBD's (derived from marijuana) for medicinal use. 

Part of the patent reads:

“Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases.The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease and HIV dementia.”

Take that with a grain of salt because I'm not a doctor.. Luckily, I haven't had to watch anyone in my family suffer from this disease--and I hope it stays that way. 

Why anyone would completely ignore this kind of science is beyond me.  

rpearlston
rpearlston

@bryan.dhn @arose4yu @franciskelly6  My condolences to you and your family.  However, the commend seems to be sarcasm, which is a legitimate form of humor meant to make you stop and think.  It's not a funny condition in the least, but sometimes a (wicked, in a positive manner) sense of humor can help to highlight something.