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Prior Antidepressant Use May Affect Patients’ Response to New Drugs — and Placebo

Having previous experience with antidepressants can change a person’s future response to both medications and to placebo, according to a new study.

The Pros and Cons of Antidepressant Use During Pregnancy

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Both antidepressant use and untreated depression in pregnant women may lead to risks for babies. A new study adds data to a troubling problem.

Good Grief! Psychiatry’s Struggle to Define Mental Illness Goes Awry

A proposed new definition of depression would include normal bereavement. Why that’s a bad idea.

Updated Guidelines for Treating Babies Exposed to Drugs in the Womb

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The question of how best to help babies who have been exposed to drugs in the womb — including prescription pain medications, antidepressants and illicit drugs like methamphetamine and cocaine — can be an emotionally charged issue.

The Perils of ‘Metabolic Chauvinism’

A reporter’s notes from a recent scientific conference

New Research on the Antidepressant-vs.-Placebo Debate

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Do antidepressants work or don’t they? A new study sheds light on why the data on drug treatment are so conflicted.

Prozac May Reduce Symptoms of Autism in Adults

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The antidepressant Prozac may alleviate repetitive behavior and obsessive-compulsive symptoms in adults with autism, reducing these defining symptoms of the disorder, according to new research.

8 Ways to Beat the Winter Blues

As the days get shorter and winter closes in, many people feel like hibernating. We start sleeping more, eating more and avoiding social contact. The effects can be particularly oppressive for people with depression, many of whom feel escalating dread as the end of daylight saving time approaches. Here are eight ways to keep the black dog [...]

What Does a 400% Increase in Antidepressant Use Really Mean?

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Antidepressant prescribing has risen nearly 400% since 1988, according to data from the Centers for Disease Control and Prevention (CDC). More than 1 in 10 Americans over age 12 now takes an antidepressant, the study finds, and yet two-thirds of those with severe symptoms of depression do not take antidepressants at all.

Tracing the Circuits of Self-Loathing in the Depressed Brain

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They say there’s a fine line between love and hate, as evidenced by the fact that the same brain circuitry processes both intense love and severe hatred. Now a new study finds that that the key wiring that connects brain regions in this circuit is weakened in people suffering from depression.