Cancer Dream Teams: Road to a Cure?

Group-think is that latest trend in cancer research. This week's cover story, available to subscribers, explains why such team efforts are becoming a necessity, and why it hasn't always been this way.

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Christopher Morris / VII for TIME

Surgeon, Jeffrey Drebin, M.D., Ph.D at Penn Medicine performing what is known as a Whippie operation.

Group-think is that latest trend in cancer research. This week’s cover story, available to subscribers here, explains why such team efforts are becoming a necessity, and why it hasn’t always been this way.

Scientists used to think they knew a lot about how cancer works, and they do. But only over the last couple of years, led by major advances in genomics, have they been able to truly understand the biological workings of this leading killer. And the knowledge has been both helpful and humbling. Cancer, it turns out, is way more complex than many scientists imagined. And it has raised the question of whether the research paradigm we use to attack cancer needs an overhaul.  Group science may be the better model for fighting cancer over the traditional approach of a narrowly focused investigator beavering away, one small grant at a time.

That’s been the premise behind Stand Up 2 Cancer’s Dream Team approach and it is gaining traction. In 2008 a group including Spider-Man producer Laura Ziskin, who lost her battle with breast cancer in 2011; Katie Couric, who lost her husband to colon cancer in 1998; and former Paramount CEO Sherry Lansing founded SU2C with the goal of attacking cancer the way you make a movie: bring the best and most talented people together, fund them generously, oversee their progress rigorously and shoot for big payoffs―on a tight schedule.

TIME Magazine Cover, April 1, 2013

(MORE: A Shot at Cancer)

There are now nine (soon to be 10) such cross-disciplinary, cross-institutional research teams backed by SU2C. One of them is taking advantage of the latest developments in epigenetics, and conducting clinical trials focused on the enzymatic on/off switches that physically settle onto the genome and regulate whether and how loudly genes genes will be expressed. This includes the mutated genes that crank out cancer cells. While science can’t do much to change the genome, epigenetic functions are manipulated all the time―sometimes inadvertently, by exposure to environmental chemicals, say; other times cleverly, by drugs. Participating in these trials has helped one patient, Tom Stanback, shrink lung tumors associated with non small cell cancer that were making it difficult to breathe and swallow. “I’m alive. I’m healthier than I’ve ever been,” says the 62-year old ex-smoker. Even better, a few other patients in the study have enjoyed what appears to be complete remission.

The epigenetics team includes geneticists, pathologists, biostatisticians, biochemists, informaticists, oncologists, surgeons, nurses and technicians, among others. “We’ve brought discovery researchers a lot closer to the clinical process: it’s an unbelievable asset,” says Dr. William Nelson, director of the Sidney Kimmel Comprehensive Cancer Center at of Johns Hopkins and a vice chairman of SU2C’s scientific committee. The success of such dream teams is prompting an important restructuring at MD Anderson, another top cancer center. President Dr. Ronald DePinho is adapting the team approach around what the institution calls its Moon Shot program. DePinho is assembling six multidisciplinary groups to “mount comprehensive attacks” on eight cancers, including lung, prostate, melanoma, and several women’s cancers that share genetic mutations. As in the SU2C effort, teams will be judged by patient outcomes, not by the number of research papers published. “Aspiring is not enough,” he says. “You must achieve.”

And given that 1.7 million people will be diagnosed with cancer this year, achievement has never been more in demand.

MORE: On the Horizon at Last, Cancer Drugs that Harness the Body’s Own Immune System

38 comments
JoyCharles
JoyCharles




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NorisRosario
NorisRosario

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JohnWilson5

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LoganHanderson
LoganHanderson

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LoganHanderson
LoganHanderson

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sophiablaze6

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OtaigbeOmokhodion
OtaigbeOmokhodion


                

















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KevinWorldsavior
KevinWorldsavior

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KevinWorldsavior
KevinWorldsavior

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anonnymous1
anonnymous1


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YutaJones

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Anniefelixs
Anniefelixs

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micheal
micheal

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v.shapoval.molbio
v.shapoval.molbio

Cancer, it turns out, is way more complex than many scientists imagined? Sooner or later we will find a way to cure all cancers? According to the Ferromagnetic Cancer Theory (Theory from The OLD TESTAMENT; Iron Conception), any human cell should be interpreted: 1) as a society of atoms and molecules; 2) as a society of organelles; 3) as a society of dia-, para-, superpara-, ferri- and ferromagnetic nanoparticles that have certain local magnetic contacts. Cancer occurs through excessive accumulation of superpara-, ferri- and ferromagnetic nanoparticles within tumor cells. Intracellular molecules FeO;Fe2O3;Fe3O4 are the main 'creators' of intracellular superpara-, ferri- and ferromagnetic nanoparticles that produce (magnetically, non-chemically) genomic rearrangements, chaotic chromosomal aberrations and chromothripsis within tumor cells. Chromothripsis occurs through one massive genomic rearrangement during a single catastrophic event in the cells history. Any cancer is a subtle iron disease; intracellular superpara-ferri-ferromagnetic 'infection'. Magnetism (a class of physical phenomena; a force of attraction or repulsion between various nano-objects) causes cancer. Any intracellular superpara-, ferri- or ferromagnetic nanoparticle produces an invisible area of influence around itself. When DNA or chromosomes come close to this region of space, they feel a pull or a push from the magnetic nanoparticle. Thus, DNA and chromosomes get various defects and disruptions. The human immune system is amazingly complex. It can recognize and remember millions of different enemies. It does not identify dia-, para-, superpara-, ferri- and ferromagnetic nanoparticles within cellular organelles. It does not identify tumor cells. Martha Tracy (American cancer researcher, Cornell University Medical College, New York City, 1905) called intracellular superpara-, ferri- and ferromagnetic FeO;Fe2O3;Fe3O4-nanoparticles - Masked Iron. Ceramic needles can suppress any tumors and large metastases. Ceramic needles can quickly create harmless infiltrations (harmless necroses; deposits of cells that die; benign capsules). Ceramic needles can enter solution [sulfur (2%) + olive oil (98%); 36.6C - 39.0C] to tumors and large metastases. Slow blood loss (even 75%) [hemoglobin control], goat’s milk diet and drinking water containing hydrogen sulfide can neutralize any micro-metastases and isolated tumor cells.   http://www.medicalnewstoday.com/opinions/122203/  ;  http://healthland.time.com/2013/04/01/the-conspiracy-to-end-cancer/  ;  http://healthland.time.com/2011/07/13/almost-every-type-of-cancer-kills-more-men-than-women-study-shows/  ;  http://healthland.time.com/2013/05/15/the-angelina-effect-times-new-cover-image-revealed/  ;  http://healthland.time.com/2013/03/21/cancer-dream-teams-road-to-a-cure/  ;  Together We (TIME, Medical News Today and Shapoval) Will Beat CANCER.

RobbieKlever
RobbieKlever

I would highly recommend the book KILLING CANCER-NOT PEOPLE by Robert G Wright. And if anyone would like more info regarding the nutritional supplements he recommends (Reliv) please contact me & I would be happy to assist you with that.   Reliv International also is working very closely in the field of epigenetics with Dr Alfredo Galvez who discovered the peptide lunasin. You can contact me via email relivrobbie@netzero.net

trucksey
trucksey

Agree with dennis. there will never be a cure for cancer or diabetes or many of the diseases man gets. There's too much money to be made in keeping us sick. Our economy would collapse if everyone were healthy. We spend more money on health care than any other country and yet we are the fattest and sickest. The answer to disease is so simple it's astonishing. It's all diet. Everything we know about diet is false. People are reversing cancer, diabetes, arthritis, high blood pressure, etc.... all through diet. I highly recommend documentaries The Gerson Miracle and Forks over Knives as well as reading the books The Natural Cures "They" Don't Want You To Know About and The China Study.

dennis.gravitt
dennis.gravitt

Although the good intentions of voluteers is admirable, the present "race", in my opinion, isn't to find a cure, but to raise money to fund drug research. For me this bodes the question, Why are we funneling the money into drug research, when the objective should be in uncovering cancer's source? As evidenced by the ever-growing population of folks with the disease, clearly we aren't winning any battle. I am all for helping people, but in the fight against cancer, the masses are being manipulated to further the causes of folks in the industry who have an incentive for this to continue.

MoKaur7
MoKaur7

If more people donated to organizations like this instead of the pointless " run for the cure" nonsense, we would actually be getting somewhere.

MarkReeser
MarkReeser

There is a cure for most cancers already, no need for poisons or more research. Most cancer can be esily cured with a plant that has been outlawed in most of the world. Research "Run from the Cure", there are lots of other information out there  if you look. Lots of people have cured themselves easily with no side effects. Google "THC cures Concer".

ihatebreastcanc
ihatebreastcanc

I got to introduce Dr Baylin, an epigenetics expert on the Stand Up to Cancer dream team, at the 2011 Metastatic Breast Cancer Network Conference at Johns Hopkins: http://ihatebreastcancer.wordpress.com/2011/10/30/dr-stephen-baylin-rock-star-of-science-and-epigenetic-genius/

My mom died of inflammatory breast cancer at age 53. I am 47 and I have metastatic breast cancer. It would be great if the Dream Team could prevent breast cancer from claiming a third generation of women in my family--and everybody's families!

Katherine O'Brien

Secretary

Metastatic Breast Cancer Network (www.mbcn.org)

fgrazz
fgrazz

Genes may be sexy but they aren't where its at.  The boring cell is the area where more study is needed.  You highlight epigenetics which is awesome yet only speak to the resulting genetic expression being from environmental chemicals and drugs...Why not consider the role of the cytosol and the external cellular environments on genetic expression?  Sure, some environmental chemicals and drugs do result in different genetic expressions (from their effect within the cytosol I might add), but our lifestyles particularly our diets are intimately connected with the resulting cues imposed on our genes.  Cancer from this angle would see the need for ONE multidisciplinary team.   Funny that when science reveals cancer is way more complex then originally imagined, most scientists don't look first at the possibility that just maybe the many manifestations of cancer just might be from a single cause.   I'd put at least some of the research funding into areas of study like  Seyfried (Boston College), and Sonneschein and Soto (Tufts) .  

nifear
nifear

I think you mean "Whipple" operation

cclayto1
cclayto1

if anyone wants to support SU2C, download the Charity Miles app. Just taking a walk can fund money for the charity. All you have to do it start your app up!

EricaHuskeyPoston
EricaHuskeyPoston

@MoKaur7 I agree, people have been "running for the cure" for years and have not come any closer to finding a cause or cure.  Not to mention, you have to pay to run/walk in the race.  I feel that I have paid enough by being diagnosed and fighting breast cancer, I  continue to ask, "where is all the money going"?

MarkReeser
MarkReeser

@MoKaur7  Pointless? Have you done any research on it? Run from the cure gives away all needed info for free right on their website. Yes they accept donations, but no donations are needed to get the info on how people can cure themselves. The government has patents on THC, and CBD's and admits that it has cancer curing properties. It is all about the money though when it comes to cancer, which is why you don't hear the cancer industry talk about this cure. How are they going to make their money if people can grow a plant freely in their back yard and cure themselves with no need for chemo, radiation, or all the treatments needed after that to just stay alive. People need to do their own research and get informed about what is really going on. No one form the government, or the health care industry are going to give you this information and lose billions in profit for giving people unneeded poison. The information is easily available you just have to look for it, it will not be spoon fed to you on the 'news'.

trucksey
trucksey

@ihatebreastcanc Read the book The China Study. It explains how animal protein turns on the cancer gene and by eliminating that can reverse the growth of cancer genes. I would run for my life to the Gerson Institute. Watch The Gerson Miracle documentary

trucksey
trucksey

@fgrazz certain foods turn on cancer genes and by eliminating them those genes can be turned off. read The China Study

MoKaur7
MoKaur7

@MarkReeser @MoKaur7 You clearly misunderstood my comment. I have cancer and I have done countless hours on researching cannabis and the effects on cancer cells. I do not support conventional treatment nor would I ever support the pink ribbon mafia. There is a big difference between RUN FOR THE CURE and RUN FROM THE CURE. Cancer is big business and hospitals/drug companies are all for profit. BIG PROFITS! You are not talking to a sheep that will be lead to slaughter by chemo and radiation.

trucksey
trucksey

@MoKaur7 @MarkReeser Please watch the documentary The Gerson Miracle and read The China Study as well as the book The Natural Cures "They" Don't Want You To Know About. Knowledge is power. 

MoKaur7
MoKaur7

@MarkReeser @MoKaur7 No worries, Mark :) Thanks for the positive vibes and I hope others realize that there really are other methods to treat and cure cancer. We have to stand up for ourselves and make informed decisions. After all, knowledge is power.  

MarkReeser
MarkReeser

@MoKaur7 @MarkReeser  Yes I did misunderstand your post, sorry about that. Now that you pointed it out I see that you did say 'run for the cure' not 'run from the cure'. It is good to hear that you have done your research and know the difference between taking poison, and doing what will help with no side effects.  I hope you beat your cancer like so many others have using Rick Simpson Oil, and that you have ways of obtaining quality product to make the oil with. Maybe our little talk has educated a few others. 

 

anonnymous10
anonnymous10

my name is MARIAN i was suffering from BREAST CANCER my pcv which is my blood level was very high,.. i heard about the power of Dr Oko healing medicine i apply for it and the doctor gave me the medicine and spiritual healing prayers to say and told me that the power of the healing drugs can cure my BREAST CANCER and he also told me to for get and stop taking the medication i was using before i really used it, and i concentrated on the medicine that Dr Oko gave to me and i was cure from CANCER i urge you all to get the DR OKO healing medicine, you reach the great man that produce the healing medicine through his email address at: solutionhome@outlook.com

douglasmike
douglasmike

i never believe that there could ever be a cure to my sickness in life, because i have been suffering from cancer disease for the past 6years now, and i have go so many places to make sure my disease get solved, i have visit so many places and taken many medications, but there could be no remedy to my disease, until i contacted Dr Udeize who finally help me out and cured my sickness, so i have nothing to say than to thank Dr Udeize who help me cure the disease called Cancer, which i think it could never be cured, thank you sir, i am here to testify of your good work, thank you sir, please if anyone has a person or he/she is suffering from this disease please contact Dr Udeize now at: Alterofgreatpowers@gmail.com

thank you sir, for your wise help:; Alterofgreatpowers@gmail.com