Synthetic Estrogens Pose Greater Clot Risk Than Natural Forms of Hormone

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In a head-to-head comparison of two major forms of hormone replacement therapy, a more natural version of estrogen proved less dangerous to the heart than a synthetic one made from the urine of pregnant mares.

While previous studies linked hormone therapy to a higher risk of breast cancer and heart disease, few looked at whether different forms of the hormone made a difference in the magnitude of these risks. So scientists from the University of Washington, Seattle studied 384 postmenopausal women between the ages of 30 and 79 who were using either conjugated equine estrogens (CEEs), or estradiol a natural, bioequivalent form of the hormone.

After monitoring the women for vascular events such as blood clots, heart attacks, and strokes between January 2003 and December 2009, they found that 68 women developed blood clots, 67 women had a heart attack and 48 women experienced a clot-related stroke. Only the risk of blood clots was statistically significant, but the researchers say that the type of estrogen pill a post-menopausal women chooses may affect her circulation and risk of vessel disorders. Women should therefore discuss the different types of hormone therapies available with their doctors, and assess the risks and benefits of each before deciding which one is appropriate for them.

3 comments
ChristyAbernathyCochran
ChristyAbernathyCochran

I have to take Estradiol 2 Mg in Am and 1 Mg in Pm and I am 34 years old. Had to have complete hysterectomy. I also have to take Testosterone biodentical cream 2Mg one time per day. I hear so many bad stories of heart attack, stroke, blood clot, breast cancer, etc. I am so scared of estrogen. I wonder if the cream is safer cause its through the skin. I only had my surgery 11 weeks ago. My whole body burns. My estrogen went from 12 to 164 now. My doctor says it needs to be between 60 to 100. I am just now slowing down on my body burning. It bothers me that I had got my ovaries removed, but he said they were shutting down any way. I have heard stories that when women have ovaries removed it shortens their life span. If any oe reads this column, please help me! I am one terrified young lady! I just happen to come across this posting. My email address is christycochran04@comcast.net Thankyou! . GOD bless you!

rosemarie40
rosemarie40

Premarin is urine from pregnant horses.  I chose estradiol lowest dose due to total hysterectomy at age 40 and at risk for osteoporosis but thinking of getting off the meds.I will see how it goes...I work out 4 to 5 times a week and really trying to eat healthy (no processed foods). I feel every woman is different and will have more or less symptoms than others and finding what works is key.

berger
berger

@rosemarie40 A lot of it has to do with small things, like how often you get up and move.  If you sit at a desk all day, or while traveling, etc, you need to get up every hour or two and move to keep blood from pooling in your legs and feet.

I learned the hard way-- when I was 24 I developed a blood clot in my leg after not moving during a long car ride.  The clot then broke off and went to my lung and nearly killed me.